Table 2

Genotype frequency distribution and association with stroke outcome at three months for MMP-2 SNPs.

Whole sample*

Ischemic subset



Genotype frequency

Genotype frequency



SNP

Genotype

Good recovery, n (%)

Poor recovery, n (%)

OR [95%CI]

P

Good recovery, n (%)

Poor recovery, n (%)

OR [95%CI]

P


rs243866

G/G

142 (67.6)

117 (57.9)

1.67 [1.10-2.52]

0.0143

125 (67.6)

83 (56.8)

1.78 [1.13-2.80]

0.0128

A/G

66 (31.4)

76 (37.6)

59 (31.9)

55 (37.7)

A/A

2 (1.0)

9 (4.5)

1 (0.5)

8 (5.5)

rs243865

C/C

141 (67.8)

117 (57.9)

1.65 [1.09-2.50]

0.0162

124 (67.8)

83 (56.8)

1.76 [1.12-2.78]

0.0143

C/T

65 (31.2)

76 (37.6)

58 (31.7)

55 (37.7)

T/T

2 (1.0)

9 (4.5)

1 (0.5)

8 (5.5)

rs857403

A/A

124 (59.3)

138 (68.3)

0.71 [0.48-1.06]

0.0909

105 (57.1)

103 (70.5)

0.62 [0.40-0.97]

0.0349

T/A

75 (35.9)

56 (27.7)

70 (38)

37 (25.3)

T/T

10 (4.8)

8 (4.0)

9 (4.9)

6 (4.1)

rs1477017

A/A

100 (47.6)

81 (40.1)

1.42 [1.01-2.00]

0.0415

86 (46.5)

55 (37.7)

1.51 [1.04-2.20]

0.0306

G/A

91 (43.3)

98 (48.5)

82 (44.3)

72 (49.3)

G/G

19 (9.0)

23 (11.4)

17 (9.2)

19 (13)

rs17301608

C/C

94 (45.0)

75 (37.3)

1.40 [1.00-1.95]

0.0510

80 (43.5)

50 (34.5)

1.47 [1.01-2.12]

0.0412

C/T

94 (45.0)

100 (49.8)

85 (46.2)

73 (50.3)

T/T

21 (10.0)

26 (12.9)

19 (10.3)

22 (15.2)

rs1053605

C/C

188 (89.5)

170 (84.2)

2.02 [1.09-3.75]

0.0227

166 (89.7)

127 (87.0)

1.82 [0.93-3.58]

0.0817

C/T

22 (10.5)

28 (13.9)

19 (10.3)

16 (11.0)

T/T

0 (0.0)

4 (2.0)

0 (0.0)

3 (2.0)

rs2241145

G/G

79 (37.8)

56 (27.9)

1.66 [1.20-2.30]

0.0021

68 (37.0)

39 (26.9)

1.67 [1.17-2.40]

0.0044

G/C

100 (47.8)

101 (50.2)

88 (47.8)

72 (49.7)

C/C

30 (14.4)

44 (21.9)

28 (15.2)

34 (23.4)

rs243849

C/C

131 (62.7)

143 (71.5)

0.70 [0.46-1.07]

0.0948

112 (60.9)

108 (75)

0.59 [0.36-0.96]

0.0314

T/C

70 (33.5)

52 (26.0)

65 (35.3)

33 (22.9)

T/T

8 (3.8)

5 (2.5)

7 (3.8)

3 (2.1)

rs183112

G/G

134 (64.1)

145 (72.9)

0.66 [0.43-1.03]

0.0669

115 (62.5)

110 (76.9)

0.54 [0.32-0.90]

0.0162

A/G

70 (33.5)

51 (25.6)

65 (35.3)

32 (22.4)

A/A

5 (2.4)

3 (1.5)

4 (2.2)

1 (0.7)

rs1992116

G/G

87 (41.6)

65 (32.3)

1.67 [1.20-2.31]

0.0018

76 (41.3)

48 (33.1)

1.68 [1.17-2.42]

0.0042

A/G

97 (46.4)

94 (46.8)

86 (46.7)

67 (46.2)

A/A

25 (12.0)

42 (20.9)

22 (12.0)

30 (20.7)


95%CI - 95% Confidence Interval.

*OR [95%CI] and P for the log-additive genetic model after adjustment for significant covariates (history of hypertension, type of stroke, and occurrence of aphasia, paresis, consciousness disturbance and complications during hospitalization).

OR [95%CI] and P for the log-additive genetic model after adjustment for significant covariates (history of hypertension, and occurrence of aphasia, paresis, consciousness disturbance and complications during hospitalization).

Significant result after Bonferroni correction.

Results were adjusted for significant covariates; Odds Ratio (OR)>1 indicates increased probability of poor recovery for the carriers of the minor allele; only associated SNPs are shown.

Manso et al. BMC Medical Genetics 2010 11:40   doi:10.1186/1471-2350-11-40

Open Data