Table 3

Summary of the SNPs significantly associated with atopy at an individual level

ECHRS Atopy vs. controls

SNP

Gene

MAF

Chromosome

Position (build36)

Pooling

Replication

Combined

rs11124858*

SGK493

0.367

2

42113828

0.0021

0.0318

0.0007^†

rs13409978*

SGK493

0.122

2

42119206

0.0007^†

0.0124

0.0001^†

rs4952590**

SGK493

0.141

2

42130425

0.0001^†

0.0008^†

1.9 × 10^-6†

rs1440095

SGK493

0.379

2

42143170

0.0098

0.1078

0.0105

rs10934938

COL29A1

0.23

3

131596325

0.1158

0.0291

0.0056

rs9402839*

MAP3K5

0.138

6

137036903

0.0355

0.0524

0.0099

rs9494554**

MAP3K5

0.095

6

137038675

0.0306

0.0035

0.0005^†

rs12483377*

COL18A1

0.108

21

45755537

0.0046

0.0607

0.0030

*SNPs found associated in the pooling-based GWA or their perfect tags (r² = 0.8) used as substitutes in the genotyping design.

**SNPs that remained significant after a 5% FDR in the pooling-based GWA

^†P-values that remain significant after Bonferroni correction (46 SNPs, p ≤ 0.001)

Castro-Giner et al. BMC Medical Genetics 2009 10:128   doi:10.1186/1471-2350-10-128