Table 3

Summary of the SNPs significantly associated with atopy at an individual level

ECHRS Atopy vs. controls


SNP

Gene

MAF

Chromosome

Position (build36)

Pooling

Replication

Combined


rs11124858*

SGK493

0.367

2

42113828

0.0021

0.0318

0.0007


rs13409978*

SGK493

0.122

2

42119206

0.0007

0.0124

0.0001


rs4952590**

SGK493

0.141

2

42130425

0.0001

0.0008

1.9 × 10-6†


rs1440095

SGK493

0.379

2

42143170

0.0098

0.1078

0.0105


rs10934938

COL29A1

0.23

3

131596325

0.1158

0.0291

0.0056


rs9402839*

MAP3K5

0.138

6

137036903

0.0355

0.0524

0.0099


rs9494554**

MAP3K5

0.095

6

137038675

0.0306

0.0035

0.0005


rs12483377*

COL18A1

0.108

21

45755537

0.0046

0.0607

0.0030


*SNPs found associated in the pooling-based GWA or their perfect tags (r2 = 0.8) used as substitutes in the genotyping design.

**SNPs that remained significant after a 5% FDR in the pooling-based GWA

P-values that remain significant after Bonferroni correction (46 SNPs, p ≤ 0.001)

Castro-Giner et al. BMC Medical Genetics 2009 10:128   doi:10.1186/1471-2350-10-128

Open Data