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Open Access Highly Accessed Research article

Animal study assessing safety of an acoustic coupling fluid that holds the potential to avoid surgically induced artifacts in 3D ultrasound guided operations

Asgeir S Jakola1234*, Arve Jørgensen5, Tormod Selbekk46, Ralf-Peter Michler7, Ole Solheim14, Sverre H Torp89, Lisa M Sagberg4, Petter Aadahl5 and Geirmund Unsgård14

Author Affiliations

1 Department of Neurosurgery, St.Olavs University Hospital, Trondheim, N-7006, Norway

2 MI Lab, Norwegian University of Science and Technology, Trondheim, Norway

3 Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway

4 National Competence Centre for Ultrasound and Image-guided Therapy, Trondheim, Norway

5 Department of Diagnostic Imaging, St.Olavs University Hospital, Trondheim, Norway

6 Department of Medical Technology, SINTEF, Trondheim, Norway

7 Department of Neurology and Clinical Neurophysiology, St.Olavs University Hospital, Trondheim, Norway

8 Department of Laboratory Medicine, Children’s and Women’s Health, Norwegian University of Science and Technology, Trondheim, Norway

9 Department of Pathology and Medical Genetics, St.Olavs University Hospital, Trondheim, Norway

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BMC Medical Imaging 2014, 14:11  doi:10.1186/1471-2342-14-11

Published: 25 March 2014

Abstract

Background

Use of ultrasound in brain tumor surgery is common. The difference in attenuation between brain and isotonic saline may cause artifacts that degrade the ultrasound images, potentially affecting resection grades and safety. Our research group has developed an acoustic coupling fluid that attenuates ultrasound energy like the normal brain. We aimed to test in animals if the newly developed acoustic coupling fluid may have harmful effects.

Methods

Eight rats were included for intraparenchymal injection into the brain, and if no adverse reactions were detected, 6 pigs were to be included with injection of the coupling fluid into the subarachnoid space. Animal behavior, EEG registrations, histopathology and immunohistochemistry were used in assessment.

Results

In total, 14 animals were included, 8 rats and 6 pigs. We did not detect any clinical adverse effects, seizure activity on EEG or histopathological signs of tissue damage.

Conclusion

The novel acoustic coupling fluid intended for brain tumor surgery appears safe in rats and pigs under the tested circumstances.

Keywords:
Brain imaging; Brain tumor; Intraoperative imaging; Ultrasound