Pattern of uniform high-signal intensity on SPIO-enhanced MR imaging. (a) The node (arrow) showed high-signal intensity before administration of superparamagnetic iron oxide (SPIO). (b) After administration of SPIO, the node showed uniform high-signal intensity and was diagnosed as malignant (arrow). (c) Histological findings confirmed it as malignant. This node was almost entirely replaced by metastatic tissue.
Motomura et al. BMC Medical Imaging 2013 13:32 doi:10.1186/1471-2342-13-32