A 2D illustration of a localized neurovascular coupling model. The local neuroactivity is represented by a ball-shaped neuroactive blob (NAB), which confines the locality and the graded strength in a cortical FOV. The red and blue lines illustrate the oxygen-rich arterioles and oxygen-poor venules. Due to spatial weighting by NAB, the cortical regions outside the NAB has no contribution to the BOLD state. (In numerical BOLD fMRI simulation, the neuron-glial clusters are considered as the extravascular parenchyma, thus being omitted).
Chen and Calhoun BMC Medical Imaging 2012 12:8 doi:10.1186/1471-2342-12-8