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Table 1
The intra-observer regional mean FA and ADC (10-3mm2/s) values (mean ± sd) for the circular and freehand ROI methods (N = 30)
		Circular ROI		Freehand ROI
Region	Parameter	1st meas.	2nd meas.	1st meas.	2nd meas.
Basal pons	FA	0.653 ± 0.065	0.637 ± 0.070	0.573 ± 0.060	0.634 ± 0.054
	ADC	0.708 ± 0.052	0.709 ± 0.060	0.709 ± 0.044	0.705 ± 0.041
Cerebral peduncle	FA	0.853 ± 0.052	0.847 ± 0.049	0.779 ± 0.049	0.817 ± 0.041
	ADC	0.711 ± 0.057	0.710 ± 0.051	0.758 ± 0.058	0.728 ± 0.033
Internal capsule, post	FA	0.734 ± 0.043	0.737 ± 0.038	0.671 ± 0.042	0.714 ± 0.037
	ADC	0.685 ± 0.024^a	0.679 ± 0.024	0.685 ± 0.015	0.688 ± 0.017
Corona radiata	FA	0.508 ± 0.053^b	0.504 ± 0.050 ^c	0.511 ± 0.049	0.524 ± 0.046 ^d
	ADC	0.644 ± 0.027	0.648 ± 0.027	0.671 ± 0.025	0.663 ± 0.022
Centrum semiovale	FA	0.505 ± 0.053	0.516 ± 0.081	0.507 ± 0.047	0.558 ± 0.055
	ADC	0.688 ± 0.034	0.693 ± 0.042	0.698 ± 0.021	0.692 ± 0.022
Uncinate fasciculus	FA	0.542 ± 0.051	0.535 ± 0.064	0.501 ± 0.039 ^e	0.552 ± 0.041
	ADC	0.773 ± 0.032	0.773 ± 0.032	0.774 ± 0.025	0.777 ± 0.032
Forceps minor	FA	0.539 ± 0.059	0.548 ± 0.074	0.466 ± 0.044 ^f	0.511 ± 0.045
	ADC	0.764 ± 0.039	0.765 ± 0.031	0.761 ± 0.029	0.760 ± 0.027
Ant corona radiata	FA	0.551 ± 0.066	0.542 ± 0.073	0.472 ± 0.038	0.508 ± 0.043
	ADC	0.742 ± 0.027	0.759 ± 0.028	0.747 ± 0.027	0.750 ± 0.027
CC genu	FA	0.834 ± 0.041	0.826 ± 0.036	0.673 ± 0.049	0.810 ± 0.033
	ADC	0.758 ± 0.067	0.766 ± 0.051	0.858 ± 0.056	0.770 ± 0.049
CC body	FA	0.750 ± 0.048	0.723 ± 0.038	0.616 ± 0.054	0.683 ± 0.063
	ADC	0.755 ± 0.073	0.839 ± 0.084	0.896 ± 0.076	0.810 ± 0.090
CC splenium	FA	0.856 ± 0.055	0.855 ± 0.050	0.742 ± 0.051	0.836 ± 0.044
	ADC	0.713 ± 0.055	0.714 ± 0.040	0.792 ± 0.047	0.732 ± 0.042

Regions with significant differences between right and left cerebral hemispheres (p< 0.05/11):

^a Posterior limb of the internal capsule ADC (circular): a) right 0.699±0.028, left 0.671±0.037.

^b,c Corona radiata FA (circular): b) right 0.484±0.055, left 0.533±0.063, c) right 0.490±0.055, left 0.518±0.058.

^d Corona radiata FA (freehand): d) right 0.508±0.048, left 0.539±0.054.

^e Uncinate fasciculus FA (freehand): e) right 0.512±0.045, left 0.490±0.039.

^f Forceps minor FA (freehand): f) right 0.481±0.046, left 0.452 ±0.048.

Hakulinen et al. BMC Medical Imaging 2012 12:30 doi:10.1186/1471-2342-12-30

Table 1