Table 1

The intra-observer regional mean FA and ADC (10-3mm2/s) values (mean ± sd) for the circular and freehand ROI methods (N = 30)
Circular ROI Freehand ROI
Region Parameter 1st meas. 2nd meas. 1st meas. 2nd meas.
Basal pons FA 0.653 ± 0.065 0.637 ± 0.070 0.573 ± 0.060 0.634 ± 0.054
ADC 0.708 ± 0.052 0.709 ± 0.060 0.709 ± 0.044 0.705 ± 0.041
Cerebral peduncle FA 0.853 ± 0.052 0.847 ± 0.049 0.779 ± 0.049 0.817 ± 0.041
ADC 0.711 ± 0.057 0.710 ± 0.051 0.758 ± 0.058 0.728 ± 0.033
Internal capsule, post FA 0.734 ± 0.043 0.737 ± 0.038 0.671 ± 0.042 0.714 ± 0.037
ADC 0.685 ± 0.024a 0.679 ± 0.024 0.685 ± 0.015 0.688 ± 0.017
Corona radiata FA 0.508 ± 0.053b 0.504 ± 0.050 c 0.511 ± 0.049 0.524 ± 0.046 d
ADC 0.644 ± 0.027 0.648 ± 0.027 0.671 ± 0.025 0.663 ± 0.022
Centrum semiovale FA 0.505 ± 0.053 0.516 ± 0.081 0.507 ± 0.047 0.558 ± 0.055
ADC 0.688 ± 0.034 0.693 ± 0.042 0.698 ± 0.021 0.692 ± 0.022
Uncinate fasciculus FA 0.542 ± 0.051 0.535 ± 0.064 0.501 ± 0.039 e 0.552 ± 0.041
ADC 0.773 ± 0.032 0.773 ± 0.032 0.774 ± 0.025 0.777 ± 0.032
Forceps minor FA 0.539 ± 0.059 0.548 ± 0.074 0.466 ± 0.044 f 0.511 ± 0.045
ADC 0.764 ± 0.039 0.765 ± 0.031 0.761 ± 0.029 0.760 ± 0.027
Ant corona radiata FA 0.551 ± 0.066 0.542 ± 0.073 0.472 ± 0.038 0.508 ± 0.043
ADC 0.742 ± 0.027 0.759 ± 0.028 0.747 ± 0.027 0.750 ± 0.027
CC genu FA 0.834 ± 0.041 0.826 ± 0.036 0.673 ± 0.049 0.810 ± 0.033
ADC 0.758 ± 0.067 0.766 ± 0.051 0.858 ± 0.056 0.770 ± 0.049
CC body FA 0.750 ± 0.048 0.723 ± 0.038 0.616 ± 0.054 0.683 ± 0.063
ADC 0.755 ± 0.073 0.839 ± 0.084 0.896 ± 0.076 0.810 ± 0.090
CC splenium FA 0.856 ± 0.055 0.855 ± 0.050 0.742 ± 0.051 0.836 ± 0.044
ADC 0.713 ± 0.055 0.714 ± 0.040 0.792 ± 0.047 0.732 ± 0.042

Regions with significant differences between right and left cerebral hemispheres (p< 0.05/11):

a Posterior limb of the internal capsule ADC (circular): a) right 0.699±0.028, left 0.671±0.037.

b,c Corona radiata FA (circular): b) right 0.484±0.055, left 0.533±0.063, c) right 0.490±0.055, left 0.518±0.058.

d Corona radiata FA (freehand): d) right 0.508±0.048, left 0.539±0.054.

e Uncinate fasciculus FA (freehand): e) right 0.512±0.045, left 0.490±0.039.

f Forceps minor FA (freehand): f) right 0.481±0.046, left 0.452 ±0.048.

Hakulinen et al.

Hakulinen et al. BMC Medical Imaging 2012 12:30   doi:10.1186/1471-2342-12-30

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