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Open Access Research article

Diabetes does not affect outcome in patients with Enterobacteriaceae bacteremia

Galo Peralta1*, M Blanca Sánchez2, M Pía Roiz3, J Carlos Garrido4, Ramón Teira5 and Fátima Mateos4

Author Affiliations

1 Director del Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Avda de Valdecilla s/n, 39008 Santander, Spain

2 Clinical Pharmacology Service, Hospital Universitario "Marqués de Valdecilla", Santander, Spain

3 Microbiology Service, Hospital Sierrallana, Torrelavega, Spain

4 Biochemistry Service, Hospital Sierrallana, Torrelavega, Spain

5 Internal Medicine Service, Hospital Sierrallana, Torrelavega, Spain

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BMC Infectious Diseases 2009, 9:94  doi:10.1186/1471-2334-9-94

Published: 13 June 2009

Abstract

Background

There is limited information about the effect of diabetes on the prognosis of patients with bacterial infections. We performed a retrospective cohort study to investigate possible correlations between diabetes and prognosis in patients with Enterobacteriaceae bacteremia.

Methods

We reviewed the medical charts of 1112 patients who were treated at a community teaching hospital for Enterobacteriaceae bacteremia from January 1997 through June 2007. Factors associated with in-hospital mortality were analyzed by logistic regression analysis.

Results

Among the 1112 patients with Enterobacteriaceae bacteremia, 181 (16.3%) were diabetic patients; 90 patients (8.1%) died while in the hospital. Compared to non-diabetic patients, diabetic patients were older (75.4 ± 11.9 years vs. 70 ± 16.6 years, p < 0.001) and had more comorbidities. However, mortality among diabetic and non-diabetic patients was not different [7.2% vs. 8.2%, RR 1.13; 95% CI (0.67–1.9); p = 0.39]. In a multivariate analysis, the variables associated with in-hospital mortality were age, the origin of the bacteremia, and the presence of immunosuppression. Diabetes was not associated with outcome.

Conclusion

In this cohort of patients with Enterobacteriaceae bacteremia, diabetes was not associated with a poorer prognosis.