Table 2

Risk factors associated with TB diagnosis

Univariate

Multivariate


No. of patients

Follow up (years)

No. of events

Rate

HR

p

HR (95% CI)

p-value


Total

3279

6815

135

1.98

Sex

Male

2307

4883

100

2.05

Female

972

1932

35

1.81

0.88

0.510

0.77 (0.52, 1.14)

0.198

Age at entry of TAHOD (years)

< = 30

1103

2203

56

2.54

31~40

1401

2944

60

2.04

0.81

0.249

0.80 (0.56, 1.16)

0.237

41+

775

1668

19

1.14

0.45

0.003

0.47 (0.28, 0.79)

0.005

Reported mode of infection

Heterosexual contact

2288

4896

102

2.08

Homosexual contact

614

1243

16

1.29

0.62

0.074

1.29 (0.74, 2.23)

0.367

Injecting drug use

132

260

11

4.23

2.03

0.026

1.03 (0.54, 1.97)

0.917

Blood products

120

197

0

0.00

---

---

---

---

Other/unknown

125

219

6

2.74

1.29

0.544

0.94 (0.41, 2.15)

0.877

CDC classification for HIV infection *

Category A

1747

3497

48

1.37

Category B

622

1158

39

3.37

2.42

<0.001

1.33 (0.86, 2.05)

0.203

Category C

1020

2160

48

2.22

1.62

0.017

1.37 (0.89, 2.10)

0.150

CD4 count (cells/μL) *

< = 50

313

251

27

10.74

51–100

312

222

15

6.74

0.64

0.162

0.69 (0.36, 1.29)

0.243

101–200

928

842

30

3.56

0.34

<0.001

0.41 (0.24, 0.69)

0.001

201–300

1224

1250

23

1.84

0.17

<0.001

0.21 (0.12, 0.37)

<0.001

301+

2225

4197

30

0.71

0.07

<0.001

0.08 (0.05, 0.14)

<0.001

Not tested

68

53

10

18.98

1.83

0.106

1.02 (0.48, 2.15)

0.969

Prior TB diagnosis

No

2562

5254

94

1.79

Yes

717

1561

41

2.63

1.47

0.038

1.08 (0.74, 1.59)

0.684

Antiretroviral treatment *

No treatment

830

985

40

4.06

Treated, 0~90 days

453

83

14

16.91

4.01

<0.001

2.52 (1.31, 4.84)

0.006

Treated, 91–180 days

674

147

9

6.11

1.45

0.328

0.96 (0.45, 2.04)

0.909

Treated, 181–360 days

1017

414

5

1.21

0.30

0.013

0.24 (0.09, 0.62)

0.003

Treated 361+ days

2452

5186

57

1.29

0.30

<0.001

0.40 (0.26, 0.61)

<0.001

Country of TB burden

High

1990

3644

115

3.16

Low/intermediate

1289

3171

20

0.63

0.21

<0.001

0.28 (0.17, 0.45)

<0.001


Rate: per 100 person years. HR: hazard ratio. CI: confidence interval.

* Time dependent variable, patients can contribute person time to more than one category thus the sum of the categories may be more than the total number of patients.

Zhou et al. BMC Infectious Diseases 2009 9:46   doi:10.1186/1471-2334-9-46

Open Data