Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
- Equal contributors
1 Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center, Bordeaux, F-33075 France
2 Centre René Labusquière (Tropical Medicine and Hygiene Branch), University Bordeaux, Bordeaux, F-33076, France
3 PPF Parasitology, University Bordeaux 2, Bordeaux, F-33076, France
4 Laboratory of Immunity and Infection, UMR-S INSERM 945, University Pierre and Marie Curie, Hôpital Pitié-Salpêtrière, 83, Boulevard de l'hôpital, Paris F-75651, France
5 Laboratory of Virology, French Armed Forces Institute of Tropical Medicine (IMTSSA), Allée du Médecin colonel Eugène Jamot, Le Pharo, BP 60109, 13262 Marseille Cedex 07, France
BMC Infectious Diseases 2009, 9:200 doi:10.1186/1471-2334-9-200Published: 10 December 2009
Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood.
We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection.
Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.