Open Access Highly Accessed Case report

Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies

Denis Malvy123, Khaled Ezzedine123*, Maria Mamani-Matsuda3, Brigitte Autran4, Hugues Tolou5, Marie-Catherine Receveur12, Thierry Pistone12, Jérome Rambert3, Daniel Moynet3 and Djavad Mossalayi12

Author Affiliations

1 Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center, Bordeaux, F-33075 France

2 Centre René Labusquière (Tropical Medicine and Hygiene Branch), University Bordeaux, Bordeaux, F-33076, France

3 PPF Parasitology, University Bordeaux 2, Bordeaux, F-33076, France

4 Laboratory of Immunity and Infection, UMR-S INSERM 945, University Pierre and Marie Curie, Hôpital Pitié-Salpêtrière, 83, Boulevard de l'hôpital, Paris F-75651, France

5 Laboratory of Virology, French Armed Forces Institute of Tropical Medicine (IMTSSA), Allée du Médecin colonel Eugène Jamot, Le Pharo, BP 60109, 13262 Marseille Cedex 07, France

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BMC Infectious Diseases 2009, 9:200  doi:10.1186/1471-2334-9-200

Published: 10 December 2009

Abstract

Background

Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood.

Case presentation

We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection.

Conclusions

Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.