Table 3

Risk of a validated medically attended local reaction following Td vaccination, by history of receipt of tetanus and diphtheria toxoid containing vaccinations1 in the prior five years, among persons with at least five years of enrollment in the MCO prior to the Td vaccination.

Age, years

History of receipt of TDCV in five years prior to Td vaccination

Number Td vaccinations

Estimated number of local reactions2

Event risk (95% CI) per 10,000 Td vaccinations

Incidence rate ratio (95% confidence interval) comparing those with and without a history of a TDCV in the prior five years


9-10

Yes

1,161

2

17.2 (2.9, 53.2)

4.6 (0.6, 35.4)

No

8,015

3

3.7 (0.8, 17.2)

11-15

Yes

2,876

2

8.2 (2.1, 32.6)

3.0 (0.8, 11.4)

No

160,933

44

2.7 (1.8, 4.1)

16-20

Yes

1,962

1

5.9 (0.8, 42.5)

1.8 (0.2, 15.6)

No

27,713

9

3.3 (1.3, 8.2)

21-25

Yes

165

0

0

Not estimable

No

6,526

6

8.7 (3.1, 24.2)

All

Yes

6,164

6

9.0 (3.7, 22.2)

2.9 (1.2, 7.2)

No

203,187

63

3.1 (2.2, 4.4)


CI = confidence interval

1 Includes Td vaccine as well as diphtheria, tetanus and pertussis vaccines administered as part of the childhood vaccination series.

2Based on multiple imputation; the total of the age-group specific estimates may not add up to the overall total due to rounding average values across imputed datasets.

Jackson et al. BMC Infectious Diseases 2009 9:165   doi:10.1186/1471-2334-9-165

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