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Open Access Highly Accessed Research article

Prevalence and risk factors for Hepatitis C and HIV-1 infections among pregnant women in Central Brazil

Zelma B Costa1, Gustavo C Machado1, Mariza M Avelino1, Clidenor Gomes Filho2, Jose V Macedo Filho2, Ana L Minuzzi2, Marilia D Turchi3, Mariane MA Stefani3, Wayner Vieira de Souza4 and Celina MT Martelli3*

Author Affiliations

1 Faculty of Medicine, Federal University of Goiás, Goiás, Brazil

2 Health State Secretariat, Goiás, Brazil, Associação de Pais e Amigos dos Excepcionais de Goiania – APAE, Goiás, Brazil

3 Institute of Tropical Medicine and Public Health, Federal University of Goiás, Goiás, Brazil

4 Oswaldo Cruz Foundation, Centro de Pesquisas Aggeu Magalhães, Pernambuco, Brazil

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BMC Infectious Diseases 2009, 9:116  doi:10.1186/1471-2334-9-116

Published: 27 July 2009

Abstract

Background

Hepatitis C (HCV) and human immunodeficiency virus (HIV) infections are a major burden to public health worldwide. Routine antenatal HIV-1 screening to prevent maternal-infant transmission is universally recommended. Our objectives were to evaluate the prevalence of and potential risk factors for HCV and HIV infection among pregnant women who attended prenatal care under the coverage of public health in Central Brazil.

Methods

Screening and counselling for HIV and HCV infections was offered free of charge to all pregnant women attending antenatal clinic (ANC) in the public health system, in Goiania city (~1.1 million inhabitants) during 2004–2005. Initial screening was performed on a dried blood spot collected onto standard filter paper; positive or indeterminate results were confirmed by a second blood sample. HCV infection was defined as a positive or indeterminate sample (EIA test) and confirmed HCV-RNA technique. HIV infection was defined according to standard criteria. Factors associated with HIV and HCV infections were identified with logistic regression. The number needed to screen (NNS) to prevent one case of infant HIV infection was calculated using the Monte Carlo simulation method.

Results

A total of 28,561 pregnant women were screened for HCV and HIV-1 in ANC. Mean maternal age was 23.9 years (SD = 5.6), with 45% of the women experiencing their first pregnancy. Prevalence of HCV infection was 0.15% (95% CI 0.11%–0.20%), and the risk increased with age (p < 0.01). The prevalence of anti-HIV infection was 0.09% (95% CI 0.06%–0.14%). Black women had a 4.9-fold (95% CI 1.42–16.95) greater risk of HIV-1 infection compared to non-black women. NNS to prevent one case of infant HIV infection ranged from 4,141 to 13,928.

Conclusion

The prevalence of HIV and HCV infections were low among pregnant women, with high acceptability rates in the opt-in strategy in primary care. Older maternal age was a risk factor for HCV and antenatal HCV testing does not fulfill the requirements for screening recommendation. The finding of higher risk of HIV-1 infection among black women despite being in consonance with the HIV-1 ethnic pattern in some American regions cannot be ruled out to be a surrogate marker of socio-economic condition.