Table 1

Effect of BCG vaccination of UK teenagers on IFN-γ responses to mycobacterial and control antigens. n= 148 (control group n = 62, vaccine group n = 86) except Ag85 where n= 43 (baseline), 50 (3 months), 49 (12 months).

Time after vaccination


Baseline

3 months

12 months


Antigen

Control

Vaccinated

Control

Vaccinated

Control

Vaccinated

M.tb PPD

% responders

23

19

31

87

19

74

Median pg/ml (IQ range)

0 (0–60)

0 (0–36)

0 (0–103)

488 (150–1178)

0 (0–46)

214 (57–822)

p value Vaccinated versus Control

0.5

< 0.001

< 0.001

M.tb Ag85

% responders

78

72

90

100

62

96

Median pg/ml (IQ range)

184 (61–721)

168 (45–426)

813 (221–1340)

1192 (865–2353)

112 (0–262)

808 (386–1865)

p value Vaccinated versus Control

0.67

0.09

0.002

RPMI

% responders

5

7

8

6

3

6

Median pg/ml (IQ range)

15 (15)

15 (15)

15 (15)

15 (15)

15 (15)

15 (15)

PHA

% responders

97

100

98

97

87

86

Median pg/ml (IQ range)

2940 (1432–3692)

3200 (2225–4700)

3807 (1496–4529)

3578 (2610–4092)

2578 (314–3357)

2797 (548–4202)

p value Vaccinated versus Control

0.09

0.76

0.85


Weir et al. BMC Infectious Diseases 2008 8:9   doi:10.1186/1471-2334-8-9

Open Data