Open Access Highly Accessed Research article

Imported Crimean-Congo hemorrhagic fever cases in Istanbul

Kenan Midilli1, Ayşen Gargılı1, Onder Ergonul2*, Gönül Şengöz3, Recep Ozturk4, Mehmet Bakar3 and Frans Jongejan56

Author Affiliations

1 Istanbul University, Cerrahpaşa Medical Faculty, Microbiology and Clinical Microbiology Department, Istanbul

2 Marmara University, School of Medicine, Infectious Diseases and Clinical Microbiology Department, Istanbul

3 Ministry of Health of Turkey, Istanbul Unit

4 Istanbul University, Cerrahpaşa Medical Faculty, Infectious Diseases and Clinical Microbiology Department, Istanbul

5 Utrecht Centre for Tick-borne Diseases (UCTD), Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, the Netherlands

6 Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, South Africa

For all author emails, please log on.

BMC Infectious Diseases 2007, 7:54  doi:10.1186/1471-2334-7-54

Published: 6 June 2007


We described a series of imported cases of Crimean-Congo Hemorrhagic Fever (CCHF) in Istanbul and investigated the genetic diversity of the virus. All the suspected cases of CCHF, who were applied to the health centers in Istanbul, were screened for CCHF virus (CCHFv) infection by using semi-nested Polymerase Chain Reaction (PCR) following RT-PCR. Simultaneous blood samples were also sent to the national reference laboratory in Ankara for serologic investigation. In 10 out of 91 patients, CCHFv was detected by PCR, and among 9 out of 10, anti-CCHFv IgM antibodies were also positive. Clinical features were characterized by fever, myalgia, and hemorrhage. The levels of liver enzymes, creatinine phosphokinase, and lactate dehydrogenase were elevated, and bleeding markers were prolonged. All the cases were treated with ribavirin. There was no fatal case. All the strains clustered within the same group as other Europe/Turkey isolates.