Table 2

Interaction as determined by means of checkerboard assay

Combination
Nr of MRSA strains (%) for which combinations gave



Synergy
No interaction
Antagonism

LVX + VA (n = 50)
16 (32)
34 (68)
0
LVX + TEC (n = 50)
9 (18)
41 (82)
0
CTX + VA (n = 50)
23 (46)
27 (54)
0
CTX + TEC (n = 50)
43 (86)
7 (14)
0
LVX + VA + AMK (n = 25)
5 (20)
20 (80)
0
LVX + TEC + AMK (n = 25)
10 (40)
15 (60)
0
LVX + VA + CAZ (n = 25)
15 (60)
10 (40)
0
LVX + TEC + CAZ (n = 25)
20 (80)
5 (20)
0
LVX + VA + FEP (n = 25)
10 (40)
15 (60)
0
LVX + TEC + FEP (n = 25)
10 (40)
15 (60)
0
LVX + VA + IPM (n = 25)
5 (20)
20 (80)
0
LVX + TEC + IPM (n = 25)
10 (40)
15 (60)
0
LVX + VA + TZP (n = 25)
5 (20)
20 (80)
0
LVX + TEC + TZP (n = 25)
20 (80)
5 (20)
0

LVX: levofloxacin; VA: vancomycin; TEC: teicoplanin; CTX: cefotaxime; AMK: amikacin; CAZ: ceftazidime; FEP: cefepime; IPM: imipenem; TZP: piperacillin/tazobactam.

Drago et al. BMC Infectious Diseases 2007 7:111   doi:10.1186/1471-2334-7-111