Table 2

Association between genotype and disease severity

Genotype

Sepsis (%)

Severe sepsis (%)

Septic shock (%)

All (%)

P value


TNF-α (G-308A)

GG

134 (60)

35 (58)

13 (65)

182 (60)

GA

80 (36)

20 (33)

6 (30)

106 (35)

AA

10 (4)

5 (9)

1 (5)

16 (5)

0.92


Il-1β (C3953T)

CC

135 (57)

32 (53)

11 (52)

178 (56)

CT

83 (35)

24 (40)

10 (48)

117 (37)

TT

18 (8)

4 (7)

0

22 (7)

0.5


PAI-1 (4G/5G)

4G-4G

67 (28)

16 (27)

7 (33)

90 (28)

4G-5G

134 (58)

37 (62)

12 (57)

183 (58)

5G-5G

35 (14)

7 (11)

2 (10)

44 (14)

0.89


uPA (C422T)

CC

135 (58)

41 (67)

11 (52)

187 (60)

CT

87 (38)

19 (31)

8 (38)

114 (36)

TT

9 (4)

1 (2)

2 (10)

12 (4)

0.30


TLR4 (A 896G)

AA

204 (91)

52 (91)

18 (86)

274 (91)

AG

19 (9)

5 (9)

3 (14)

27 (9)

GG

0

0

0

0

0.52


CD14 (C-159T)

CC

72 (31)

13 (22)

7 (33)

92 (29)

CT

117 (50)

30 (51)

9 (43)

156 (50)

TT

45 (19)

16 (27)

5 (24)

66 (21)

0.57


TNF-α: tumor necrosis factor alpha; Il-1β: interleukin-1 beta; PAI-1: plasminogen activator inhibitor 1; uPA: urokinase-type plasminogen activator; TLR4: toll-like receptor 4; CD14: cluster of differentiation 14; A: adenine; T: thymidine; C: cytosine; G: guanine

Jessen et al. BMC Infectious Diseases 2007 7:108   doi:10.1186/1471-2334-7-108

Open Data