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Open Access Highly Accessed Research article

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong1, WK Eddie Ip1, Gloria Hoi Wan Tso1, Man Wai Ng1, Wilfred Hing Sang Wong1, Helen Ka Wai Law1, Raymond WH Yung2, Eudora Y Chow3, KL Au4, Eric YT Chan5, Wilina Lim6, JS Malik Peiris7 and Yu Lung Lau1*

Author Affiliations

1 Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

2 Department of Pathology, Pamela Nethersole Youde Hospital, Hong Kong SAR, China

3 Department of Pathology, United Christian Hospital, Hong Kong SAR, China

4 Princess Margaret Hospital, Hong Kong SAR, China

5 Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China

6 Government Virus Unit, Department of Health, Hong Kong SAR, China

7 Department of Microbiology, The Hong Kong Jockey Club Research Centre, Pokfulam, The University of Hong Kong, Hong Kong SAR, China

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BMC Infectious Diseases 2006, 6:82  doi:10.1186/1471-2334-6-82

Published: 4 May 2006

Abstract

Background

Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).

Methods

A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS.

Results

IFN-γ +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility.

Conclusion

IFN-γ +874A allele was shown to be a risk factor in SARS susceptibility.