The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
- Equal contributors
1 Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
2 Department of Pathology, Pamela Nethersole Youde Hospital, Hong Kong SAR, China
3 Department of Pathology, United Christian Hospital, Hong Kong SAR, China
4 Princess Margaret Hospital, Hong Kong SAR, China
5 Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
6 Government Virus Unit, Department of Health, Hong Kong SAR, China
7 Department of Microbiology, The Hong Kong Jockey Club Research Centre, Pokfulam, The University of Hong Kong, Hong Kong SAR, China
BMC Infectious Diseases 2006, 6:82 doi:10.1186/1471-2334-6-82Published: 4 May 2006
Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).
A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS.
IFN-γ +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility.
IFN-γ +874A allele was shown to be a risk factor in SARS susceptibility.