Table 3

Results of logistic regression models predicting overall change in blood CD4 cell count during ART. Responses are defined as either (i) the risk of immunological non-response (an increase of <50 cells/μl) or (ii) failure to attain an absolute CD4 cell count of ≥ 200 cells/μl after 48 weeks ART.

Risk of immumological non-respouse at 48 weeks

Risk of failure to attain CD4 cell count of ≥ 200 cells/μl at 48 weeks

OR

(95% CI)

P value

OR

(95% CI)

P value


Age (years)

<30

1.0

1.0

30–39

3.15

(1.09, 9.15)

0.035

1.34

(0.66, 2.72)

0.41

>40

3.88

(1.13, 13.39)

0.032

3.52

(1.55, 7.99)

0.003

Sex

Female

1.0

Male

0.42

(0.13, 1.39)

0.16

1.73

(0.90, 3.35)

0.10

Baseline CD4 count

>150

1.0

1.0

100–149

0.63

(0.23, 1.72)

0.37

2.49

(0.89, 6.96)

0.08

50–99

0.18

(0.05 0.70)

0.013

5.97

(2.29, 15.58)

<0.001

<50

0.18

(0.05, 0.72)

0.016

12.11

(4.43, 33.14)

<0.001

WHO clinical stage

1 & 2

1.0

1.0

3

1.12

(0.37, 3.40)

0.84

1.32

(0.54, 3.26)

0.54

4

2.11

(0.63, 7.03)

0.22

1.19

(0.45, 3.17)

0.72

Baseline viral load

<5 log10

1.0

1.0

>5 log10

0.21

(0.07, 0.66)

0.008

0.47

(0.26, 0.86)

0.014

Follow-up viral load

<400 all visits

1.0

1.0

>400 any visit

4.25

(1.30, 13.87)

0.017

3.00

(1.14, 7.90)

0.026


Lawn et al. BMC Infectious Diseases 2006 6:59   doi:10.1186/1471-2334-6-59

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