Table 1

Clinical Characteristics of enrolled subjects by genotype (N = 266).
Clinical characteristics
 HbSS N = 148
 HbSC N = 85
 HbSβ0 N = 6
 HbSβ+ N = 22
 Sickle variants* N = 5
Age yr
 26.4 ± 2.6
 27 ± 2.3
 25.9 ± 2.3
 26.5 ± 2.5
 25.1 ± 2.5
†Gender (M:F)
 71:77
 38:47
 2:4
 13:9
 4:1
#Creatinine μmol/L
 45.7 ± 9.4a
 63.3 ± 11.7b
 70.7 ± 23.1b
 61.9 ± 12.4b
 62 ± 20.4a
#Uric Acid mmol/L
 0.3 ± 0.1a
 0.3 ± 0.1a
 0.4 ± 0.1a
 0.4 ± 0.3b
 0.3 ± 0.1a
#Haemoglobin g/L
 80.2 ± 9.9a
 108.2 ± 8b
 91.6 ± 11.8b
 109.9 ± 12.4b
 124 ± 22.1b
#Nucleated Blood cells × 109/Lc
 15.9 ± 3.2a
 10.2 ± 2.9b
 13.3 ± 2.2b
 9.2 ± 2.7b
 9.9 ± 2.5b
†Proteinuria ≥ trace : No proteinuria (n = 182)
 17
 7
 0
 1
 0
†Positive History of gram negative sepsis
 2
 2
 0
 0
 0
†Positive recorded history of ever having UTI
 50
 25
 2
 1
 1

Values are means ± sd ; † values are counts. Abbreviations – HbSS = Homozygous sickle cell disease, HbSC= Sickle cell-haemoglobin C, HbSβ0 = Sickle cell-β0 thalassemia, HbSβ+ = Sickle cell-β+ thalassemia; UTI= Urinary Tract Infections.

* Sickle variants include sickle cell-hereditary persistence of foetal haemoglobin, sickle cell -haemoglobin O Arab, sickle cell -haemoglobin Lepore-Boston.

# Significant difference in mean values by genotype. Dissimilar superscript to HbSS values are significantly different (p < 0.03)

Cumming et al. BMC Infectious Diseases 2006 6:46   doi:10.1186/1471-2334-6-46