Digital clubbing in tuberculosis – relationship to HIV infection, extent of disease and hypoalbuminemia
1 Department of Medicine, Makerere University and Mulago Hospital, Kampala, Uganda
2 Department of Medicine, Division of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA
3 Departments of Pathology and Molecular Medicine, Medicine, and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton ON, Canada
4 L424 St. Joseph's Hospital, 50 Charlton Ave. E., Hamilton ON L8N 4A6, Canada
BMC Infectious Diseases 2006, 6:45 doi:10.1186/1471-2334-6-45Published: 10 March 2006
Digital clubbing is a sign of chest disease known since the time of Hippocrates. Its association with tuberculosis (TB) has not been well studied, particularly in Africa where TB is common. The prevalence of clubbing in patients with pulmonary TB and its association with Human Immunodeficiency Virus (HIV), severity of disease, and nutritional status was assessed.
A cross-sectional study was carried out among patients with smear-positive TB recruited consecutively from the medical and TB wards and outpatient clinics at a public hospital in Uganda. The presence of clubbing was assessed by clinical signs and measurement of the ratio of the distal and inter-phalangeal diameters (DPD/IPD) of both index fingers. Clubbing was defined as a ratio > 1.0. Chest radiograph, serum albumin and HIV testing were done.
Two hundred patients (82% HIV-infected) participated; 34% had clubbing by clinical criteria whilst 30% had clubbing based on DPD/IPD ratio. Smear grade, extensive or cavitary disease, early versus late HIV disease, and hypoalbuminemia were not associated with clubbing. Clubbing was more common among patients with a lower Karnofsky performance scale score or with prior TB.
Clubbing occurs in up to one-third of Ugandan patients with pulmonary TB. Clubbing was not associated with stage of HIV infection, extensive disease or hypoalbuminemia.