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Open Access Research article

Evaluation of the ICT Tuberculosis test for the routine diagnosis of tuberculosis

Gozde Ongut1*, Dilara Ogunc1, Filiz Gunseren2, Candan Ogus3, Levent Donmez4, Dilek Colak1 and Meral Gultekin1

Author Affiliations

1 Department of Medical Microbiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey

2 Department of Infectious Diseases and Clinical Microbiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey

3 Department of Respiratory Medicine, Akdeniz University, Faculty of Medicine, Antalya, Turkey

4 Department of Public Health, Akdeniz University, Faculty of Medicine, Antalya, Turkey

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BMC Infectious Diseases 2006, 6:37  doi:10.1186/1471-2334-6-37

Published: 27 February 2006

Abstract

Background

Rapid and accurate diagnosis of tuberculosis (TB) is crucial to facilitate early treatment of infectious cases and thus to reduce its spread. To improve the diagnosis of TB, more rapid diagnostic techniques such as antibody detection methods including enzyme-linked immunosorbent assay (ELISA)-based serological tests and immunochromatographic methods were developed. This study was designed to evaluate the validity of an immunochromatographic assay, ICT Tuberculosis test for the serologic diagnosis of TB in Antalya, Turkey.

Methods

Sera from 72 patients with active pulmonary (53 smear-positive and 19 smear-negative cases) and eight extrapulmonary (6 smear-positive and 2 smear-negative cases) TB, and 54 controls from different outpatient clinics with similar demographic characteristics as patients were tested by ICT Tuberculosis test.

Results

The sensitivity, specificity, and negative predictive value of the ICT Tuberculosis test for pulmonary TB were 33.3%, 100%, and 52.9%, respectively. Smear-positive pulmonary TB patients showed a higher positivity rate for antibodies than smear-negative patients, but the difference was not statistically significant. Of the eight patients with extrapulmonary TB, antibody was detected in four patients.

Conclusion

Our results suggest that ICT Tuberculosis test can be used to aid TB diagnosis in smear-positive patients until the culture results are available.