Table 1

Decreased anti-HIV-1 activity of polymeric candidate microbicides in the presence of human seminal plasma

Polymer

HIV-1 IIIB

HIV-1 BaL


ED50 μg/ml

ED50SP μg/ml

ED50SP: ED50 ratio

ED50 μg/ml

ED50SP μg/ml

ED50SP: ED50 ratio


Poly (naphthalene sulfonate)

1.1

17.3

15.7

37.5

141

3.8

Cellulose sulfate

1.6

64.7

40.4

7.1

401

56.5

Carrageenan

1.4

63.4

45.6

6.3

149

23.7

Cellulose acetate 1,2-benzenedi-carboxylate

1.0

72.7

72.7

9.8

141

14.4

Polystyrene sulfonate

2.2

36.1

16.4

12.8

389

30.4


SP = seminal plasma added

Neurath et al. BMC Infectious Diseases 2006 6:150   doi:10.1186/1471-2334-6-150

Open Data