|
Association between surgical site infections and duration, timing, and antibiotic prophylaxis agent, adjusted for age, sex, ASA score, and duration of operation |
|||||||
| Predictor variable |
N |
Infection |
Rate* |
Relative risk |
|||
|
|
|||||||
| Crude |
95% CI |
Adjusted** |
95% CI |
||||
|
|
|||||||
| Duration of antibiotic prophylaxis |
|||||||
| None |
167 |
5 |
3.0 |
1.00 |
Reference |
1.00 |
Reference |
| 1 day |
1159 |
12 |
1.0 |
0.34 |
0.12–0.97 |
0.30 |
0.10–0.88 |
| >1 day |
813 |
9 |
1.1 |
0.36 |
0.12–1.09 |
0.32 |
0.10–0.98 |
| Time of first antibiotic dose administration |
|||||||
| None |
167 |
5 |
3.0 |
1.00 |
Reference |
1.00 |
Reference |
| >1 hour preoperatively |
1004 |
8 |
0.8 |
0.26 |
0.08–0.81 |
0.22 |
0.07–0.70 |
| ≤ 1 hour preoperatively or interoperation |
814 |
9 |
1.1 |
0.36 |
0.12–1.09 |
0.33 |
0.11–1.02 |
| Postoperatively |
154 |
4 |
2.6 |
0.86 |
0.23–3.28 |
0.78 |
0.20–3.00 |
| Antibiotic agent |
|||||||
| None |
167 |
5 |
3.0 |
1.00 |
Reference |
1.00 |
Reference |
| Single dose combination metronidazole and gentamicin |
766 |
8 |
1.0 |
0.34 |
0.11–1.06 |
0.28 |
0.09–0.90 |
| Combination metronidazole and gentamicin within 1 day |
130 |
1 |
0.8 |
0.25 |
0.03–2.18 |
0.22 |
0.03–1.98 |
| Combination metronidazole and gentamicin > 1 day |
370 |
4 |
1.1 |
0.35 |
0.09–1.34 |
0.29 |
0.08–1.12 |
| Others*** |
706 |
8 |
1.1 |
0.37 |
0.12–1.15 |
0.37 |
0.12–1.15 |
|
* Rate = infections/100 operations ** Adjusted for age, sex, ASA score, and duration of operation *** Others: Penicillin, amoxicillin, amoxicillin/clavulanate, ampicillin, cloxacillin, cefazolin, cephalexin, cefotaxime, ceftriaxone, ceftazidime, cefdinir, cefoxitin, ofloxacin, norfloxacin, cotrimoxazole, chloramphenical, fosfomycin, clindamycin, and amikacin. | |||||||
Kasatpibal et al. BMC Infectious Diseases 2006 6:111 doi:10.1186/1471-2334-6-111 |
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