Research article
Correlation between human papillomavirus infection and bladder transitional cell carcinoma
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* Corresponding author: SMM Hosseini Moghaddam h_sasan@hotmail.com
1 Assistant Professor Of Urology, Shohada Tajrish Hospital, Shahid Beheshti University Of Medical Sciences, Urology and Nephrology Research Center, Tehran, Iran
2 Resident Of Urology, Shohada Tajrish Hospital, Shaeed Beheshti University Of Medical Sciences, Urology and Nephrology Research Center, Tehran, Iran
3 Research Consultant, Assistant Professor Of Infectious Diseases And Tropical Medicine, Master of Public Health, Urology and Nephrology Research Center, Shaheed Beheshti University Of Medical Sciences, Tehran, Iran
4 Cellular and Molecular Biology Research Center, Urology and Nephrology Research Center, Shaheed Beheshti University of Medical Sciences, Urology and Nephrology Research Center, Tehran, Iran
5 Urology and Nephrology Research Center (UNRC), Shohada Tajrish Hospital, Shaheed Beheshti University of Medical Science, Tehran Iran
BMC Infectious Diseases 2005, 5:102 doi:10.1186/1471-2334-5-102
Published: 8 November 2005Abstract
Background
To determine the association of human papillomavirus infection (HPV) and transitional cell carcinoma (TCC).
Methods
Using polymerase chain reaction, fifty-nine bladder tissue specimens of patients with transitional cell carcinoma of bladder compared with 20 bladder samples of cases with non-neoplastic disorders.
Results
Male to female ratio was similar in the two groups (50/9 vs. 16/4, P = 0.62). Mean age was 67 ± 10.8 years and 52 ± 20.3 years in the case and control groups, respectively (P = 0.6). Of the 59 tissue specimens with diagnosis of transitional cell carcinoma, HPV DNA was detected in 21 (35.6%) samples, while it was present in only one sample (5%) in the control group (P = 0.008). HPV18 was the most common type of virus with the incidence rate of 17/21(81%).
Conclusion
HPV might play a causative role in transitional cell carcinoma of bladder in our geographic area.