Email updates

Keep up to date with the latest news and content from BMC Infectious Diseases and BioMed Central.

Open Access Research article

cART prescription trends in a prospective HIV cohort in rural Tanzania from 2007 to 2011

Fabian Christoph Franzeck14*, Emilio Letang134, Geoffrey Mwaigomole2, Boniphace Jullu2, Tracy R Glass14, Daniel Nyogea12, Christoph Hatz14, Marcel Tanner14 and Manuel Battegay45

Author Affiliations

1 Swiss Tropical and Public Health Institute (SwissTPH), Socinstrasse 57, CH-4051 Basel, Switzerland

2 Ifakara Health Institute (IHI), Ifakara, United Republic of Tanzania

3 Barcelona Centre for International Health Research (CRESIB-Hospital Clínic, Universitat de Barcelona), Barcelona, Spain

4 University of Basel, Basel, Switzerland

5 Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland

For all author emails, please log on.

BMC Infectious Diseases 2014, 14:90  doi:10.1186/1471-2334-14-90

Published: 20 February 2014

Abstract

Background

Since 2010, World Health Organization (WHO) guidelines discourage using stavudine in first-line regimens due to frequent and severe side effects. This study describes the implementation of this recommendation and trends in usage of antiretroviral therapy combinations in a cohort of HIV-positive patients in rural Tanzania.

Methods

We analyzed longitudinal, prospectively collected clinical data of HIV-1 infected adults initiating antiretroviral therapy within the Kilombero Ulanga Antiretroviral Cohort (KIULARCO) in Ifakara, Tanzania from 2007-2011.

Results

This analysis included data of 3008 patients. Median age was 38 (interquartile range [IQR] 31-45) years, 1962 (65.2%) of all subjects were female, and median CD4+ cell count at enrollment was 168 cells/mm3 (IQR 81-273). The percentage of prescriptions containing stavudine in initial regimens fell from a maximum of 75.3% in 2008 to 10.7% in 2011. TDF/FTC/EFV became available in 2009 and was used in 41.9% of patients initiating cART in 2011. An overall on-treatment analysis revealed that d4T/3TC/NVP and AZT/3TC/EFV were the most prescribed combinations in each year, including 2011 (674 [36.5%] and 641 [34.7%] patients, respectively). Of those receiving stavudine in 2011, 659 (89.1%) initiated it before 2011.

Conclusions

Initial cART with stavudine declined to low levels according to recommendations but the overall use of stavudine remained substantial, as individuals already on cART containing stavudine were not changed to alternative drugs. Our findings highlight the critical need to exchange stavudine in treatment regimens of patients who initiated therapy in earlier years.

Keywords:
cART; Regimen; Combination; Africa; Stavudine; HIV; AIDS