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Open Access Highly Accessed Research article

HPV genotypes and associated cervical cytological abnormalities in women from the Pearl River Delta region of Guangdong province, China: a cross-sectional study

Lipeng Jing1, Xingming Zhong2, Weihuang Huang1, Yang Liu1, Man Wang1, Zhulin Miao2, Xiaoping Zhang3, Jing Zou3, Baowen Zheng4, Congde Chen4, Xiaoman Liang4, Guang Yang1, Chunxia Jing1* and Xiangcai Wei12*

Author Affiliations

1 Department of Epidemiology, Medical School of Jinan University, Jinan, Guangdong Province, China

2 Family Planning Research Institute of Guangdong, Guangzhou, Guangdong, China

3 Clinical Laboratory Center of the Beijing Genomics Institute (BGI), Shenzhen, Guangdong Province, China

4 Kingmed Center for Clinical Laboratory, Guangzhou, Guangdong Province, China

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BMC Infectious Diseases 2014, 14:388  doi:10.1186/1471-2334-14-388

Published: 12 July 2014

Abstract

Background

It is important to understand the specific HPV genotype distribution in screen-detected lesions. HPV Genotype is helpful for separating HPV-positive women at greater risk of cancer from those who can regress spontaneously and for preventing cervical cancer at early stage. The aim of this study was to investigate the high-risk HPV genotype distribution among cervical cytology abnormality in Pearl River Delta Region, Southern China

Methods

5585 HPV-infected women were screened from 77069 women in Pearl River Delta Region. Information was obtained from 3226 screened subjects through questionnaires and personal interviews. Exfoliated cervical cells were collected by doctors for HPV test with MassARRAY (Sequenom, Sandiego, CA) technique based on the matrix-assisted laser desorption/ionization time-of flight (MALDI-TOF) mass spectrometry (MS). The ThinPrep cytology test was performed to screen for cervical cancer. Unconditional logistic was used to determine the most common HPV carcinogenic types.

Results

Of the 3226 HPV-positive samples tested, 1744 (54.1%) with normal cervical cytology, 1482 (45.9%) with abnormal cytology. The five most common HPV types in this study were HPV16 (20.2%), HPV52 (17.1%), HPV58 (13.2%), HPV18 (9.5%), HPV6 (7.6%). Overall, HPV16 (OR = 10.5, 95% CI: 3.7 ~ 29.6), HPV33 (OR = 9.1, 95% CI: 2.8 ~ 29.2), HPV58 (OR = 6.3, 95% CI: 2.1 ~ 18.6), HPV31 (OR = 4.5, 95% CI: 1.3 ~ 15.5), multiple genotype infection (OR = 3.0, 95% CI: 1.7 ~ 14.7), especially HPV16 and HPV33, increased the risk of cytology abnormalities.

Conclusions

HPV16, HPV31, HPV33, HPV58, and multiple HPV genotype infection increased the risk of cytology abnormalities in Pearl River Delta Region and might be useful for the screening, preventing, treating, and monitoring of pre-cancer lesions in southern China.

Keywords:
Human papillomavirus; Cytology; Cross-sectional study; Infection