Open Access Highly Accessed Research article

Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults

Paul Gillard1*, Daniel Wai Sing Chu2, Shinn-Jang Hwang3, Pan-Chyr Yang4, Prasert Thongcharoen5, Fong Seng Lim6, Mamadou Dramé7, Karl Walravens8 and François Roman8

Author Affiliations

1 GlaxoSmithKline Vaccines, Wavre, Belgium

2 Department of Medicine, Queen Mary Hospital Hong Kong, Hong Kong, China

3 Department of Family Medicine, Taipei Veterans General Hospital and National Yang-Ming University, School of Medicine, Taipei, Taiwan

4 College of Medicine, National Taiwan University, Taipei, Taiwan

5 Faculty of Medicine, Mahidol University, Nakon Pathom, Thailand

6 National Healthcare Group Polyclinics, Singapore, Republic of Singapore

7 GlaxoSmithKline Vaccines, King of Prussia, PA, USA

8 GlaxoSmithKline Vaccines, Rixensart, Belgium

For all author emails, please log on.

BMC Infectious Diseases 2014, 14:142  doi:10.1186/1471-2334-14-142

Published: 15 March 2014

Additional files

Additional file 1:

Cell-mediated immune responses against the booster vaccine strain (A/Indonesia/5/2005) primary vaccine strain (A/Vietnam/1194/2004) after heterologous booster vaccine at Month 6, 12, 36, and persistence of responses up to 48 months follow-up (cell-mediated immunity subset).

Format: DOCX Size: 29KB Download file

Open Data