Table 1

Summary of risk factors associated with carbapenem-resistant K. pneumoniae infection
Risk factor Case patients (n = 20) Control patients (n = 40) Univariable analysis Multivariable analysis
OR (95% CI) p OR (95% CI) p
Male sex 13 (65.0) 21 (52.5) 0.59 (0.19-1.81) 0.36
Mean Age (years) 59.6 64.9 5.35 (−6.89-17.59) 0.38
McCabe score
 Rapidly fatal 4 (20.0) 11 (27.5) 1.52 (0.42-5.55) 0.75
 Potentially fatal/Non-fatal 16 (80.0) 29 (72.5)
Charlson score ≥ 3 11 (55.0) 12 (30.0) 2.85 (0.94-8.66) 0.06
Transplant receipt 7 (35.0) 6 (15.0) 0.33 (0.09-1.16) 0.10
Prior corticosteroid use 16 (80.0) 22 (55.0) 0.31 (0.09-1.08) 0.06
Prior surgery 14 (70.0) 22 (55.0) 0.53 (0.17-1.64) 0.27
Dialysis 6 (30.0) 6 (15.0) 0.42 (0.12-1.49) 0.17
ICU stay* 20 (100) 32 (80.0) 0.62 (0.49-0.76) 0.03 - -
Mean APACHE II score at admission 22.1 16.4 1.10 (1.02-1.19) 0.02 1.10 (0.97-1.25) 0.13
Mean SOFA score at admission 7.35 5.63 1.14 (0.98-1.32) 0.09
Mean length of stay before infection (days) 45.5 27 0.11
Device use
 CVC 17 (85.0) 23 (57.5) 4.18 (1.10-16.7) 0.04 0.05 (0.01-2.20) 0.12
 Mechanical ventilation 4 (20.0) 5 (12.5) 0.57 (0.13-2.42) 0.46
 Urinary catheter 12 (60.0) 29 (72.5) 1.56 (0.51-4.77) 0.44
Mean device use (days)
 CVC
 Urinary catheter 23.5 12.2 0.02 1.07 (0.99-1.16) 0.07
 Mechanical ventilation 13.0 17.1 0.56
21.0 22.0 0.98
Prior antimicrobial use** 20 (100) 31 (77.5) 1.67 (1.32-2.05) 0.02 - 1.0

Univariable analysis shows carbapenem-resistant K. pneumoniae infection was associated with previous ICU stay, central venous catheter catheterization, a longer central venous catheter use, and exposure to antimicrobials. Multivariable analysis demonstrated that only the length of central venous catheter was independently associated with carbapenem resistance.

*The variable ICU stay was constant for all selected cases. Since a constant was requested in the model, it was removed from the analysis.

**The prior use of antimicrobial agents was considered independently of the antimicrobial class used, for the multivariate analysis.

Abbreviations used: CVC, central venous catheter.

Figures in parentheses represent percentage values unless otherwise stated.

Correa et al.

Correa et al. BMC Infectious Diseases 2013 13:80   doi:10.1186/1471-2334-13-80

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