Genetic variability of HCV quasispecies in samples collected over time. A) Genetic complexity calculated using normalized entropy (Shannon entropy). B) Diversity of HCV quasispecies calculated using genetic distance (p-distance). Patterns of response to therapy are represented by colours: sustained virological responders in red, non-responders in blue and end-of-treatment responders in green. C) Genetic diversity by the mean of genetic distance of each time-point collected. On the left: the end-of-treatment-responders. On the right: non-responders. D) Genetic diversity by the mean of genetic distance between every sample and baseline. Comparisons between non-responders and end-of-treatment responders. P=value calculated using Fisher’s test or paired t-test.
Jardim et al. BMC Infectious Diseases 2013 13:61 doi:10.1186/1471-2334-13-61