Table 4

Characteristics for ICU admission and death among patients with asthma hospitalized with 2009 Pandemic Influenza A (H1N1) Infection: comparison of patients with asthma admitted to an ICU or who died versus patients with asthma who were not admitted to an ICU and survived (n = 137)
Characteristic Intensive care unit or deaths Non-intensive care unit survivors P-Value*
No. (%) (n = 38) No. (%) (n = 99)
Median days from onset to admission (range) 2 (0 – 15) 2 (0 – 20) 0.52
Admission within 2 days of illness onset 20 (53) 54 (55) 0.80
Median length of stay- days (range) 6 (0 – 47) 2 (1 – 10) <0.01
Age 2–17 years old 12/38 (32) 42/99 (42) 0.24
Underlying medical condition excluding asthma 20 (53) 44 (44) 0.39
Pregnancy 3 (8) 5 (5) 0.83
Current smoker 7 (22) 16 (18) 0.82
Obese or morbidly obese 8/29 (28) 21/69 (30) 0.29
Tachypnea 23/38 (61) 37/99 (37) <0.01
Tachycardia 28/38 (74) 60/99 (60) 0.12
Mechanical ventilation 16/38 (42) 0/99 (0) <0.01
Acute respiratory distress syndrome 9/38 (24) 0/99 (0) <0.01
Sepsis syndrome 6/38 (16) 0/99 (0) <0.01
Pneumonia at admission 22/37 (60) 23/86 (27) <0.01
Seasonal flu vaccination 8/25 (32) 23/29 (39) 0.45
Influenza antiviral agent receipt
 Any during hospitalization 32/38 (84) 68/99 (69) 0.07
 ≤2 days of illness onset 13/32 (41) 36/66 (55) 0.14
 ≤2 days of admission 22/30 (73) 57/62 (92) 0.02
Median days from illness onset to antiviral initiation (range) 3 (0 – 15) 2 (0 – 15) 0.15
Other treatment
 Antibiotics 35/38 (92) 64/99 (65) <0.01
 Steroids 25/38 (66) 58/99 (59) 0.45

*P-Values stratified by age-group.

Body-Mass Index (BMI) was calculated for a subset of patients for whom height and weight were available to determine obesity (BMI 30–39.9 in adults ≥18 years or BMI percentile 95–100 in children 2 to 18 years old) and morbid obesity (BMI ≥40 in adults only); pregnant women were excluded from this calculation.

McKenna et al.

McKenna et al. BMC Infectious Diseases 2013 13:57   doi:10.1186/1471-2334-13-57

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