Table 1

Results on hospitalized RVGE cases, costs and QALYs for the original study and with new hospitalization data and herd protection
No vaccination Vaccination Difference
Individuals aged <5y Individuals aged ≥5y Individuals aged <5y Individuals aged ≥5y Individuals aged <5y Individuals aged ≥5y
Number of hospitalized cases from the original study1
Community accquired 2,817 161 353 161 2,464 0
Nosocomial 421 149 106 149 315 0
Number of hospitalized cases from the original study (including herd protection for children <5 years)
Community accquired 2,817 161 155 161 2,662 0
Nosocomial 421 149 23 149 398 0
Number of hospitalized cases using the updated hospitalization data (and herd protection for <5 years)2
Community accquired 4,241 223 233 223 4,008 0
Nosocomial 634 207 35 207 599 0
Number of hospitalized cases using the updated hospitalization data and herd protection (for <25 years)2
Community accquired 4,241 223 233 180 4,008 43
Nosocomial 634 207 35 167 599 40
Discounted cost and QALYs from the original study1
Total costs (direct and indirect)3 9,663,000 6,519,000 2,074,000 6,519,000 7,589,000 0
Total QALYs 173 NA4 64 NA4 109 NA4
Discounted cost and QALYs from the original study (including herd protection for <5 years only)
Total costs (direct and indirect)3 €9,663,000 €6,519,000 €969,000 €6,519,000 €8,694,000 €0
Total QALYs 173 NA4 32 NA4 141 NA4
Discounted cost and QALYs using the updated hospitalization data (and herd protection <5 years)2
Total costs (direct and indirect)3 €13,246,000 €6,937,000 €1,203,000 €6,937,000 €12,043,000 €0
Total QALYs 207 NA4 37 NA4 170 NA4
Discounted costs and QALYs using updated hospitalization data and herd protection (for <25)2
Total costs (direct and indirect costs)3 €13,246,000 €6,937,000 €1,203,000 €6,833,000 €12,043,000 €104,000
Total QALYs 207 NA4 37 NA4 170 NA4

1Herd protection was not included in the base case analysis; 2Herd protection for individuals aged less than 5 years of age was included in the same way as in the scenario analysis of Rozenbaum et al. [1]; 3Costs are excluding vaccination costs; 4No utility losses were available for individuals aged 5 years and older and death was conservatively assumed to occur in individuals aged less than 5 years of age only in the absence of any reported deaths in older ages.

Tu et al.

Tu et al. BMC Infectious Diseases 2013 13:54   doi:10.1186/1471-2334-13-54

Open Data