Table 4

Results from multivariable Cox proportional hazards regression models to identify independent associations between factors at the time of diagnosis of NADC and subsequent all-cause mortality and cancer-specific mortality for any NADC, and lung cancer, anal cancer and Hodgkin’s lymphoma separately
All-cause mortality Cancer-specific mortality
RH [95% CI] p-value RH [95% CI] p-value
Any NADC
Gender Male 1.69 [1.21, 2.36] 0.002 1.59 [1.11, 2.26] 0.01
Female Ref. - Ref. -
Mode of infection Heterosexual Ref. - Ref. -
MSM 0.84 [0.63, 1.11] 0.22 0.84 [0.62, 1.13] 0.24
IDU 1.35 [0.98, 1.87] 0.07 1.23 [0.87, 1.74] 0.24
Other/unknown 0.78 [0.48, 1.26] 0.30 0.72 [0.42, 1.22] 0.22
Ethnic group White Ref. - Ref. -
Non-white/other/not collected 1.25 [0.99, 1.56] 0.06 1.18 [0.93, 1.49] 0.19
Smoking status Current smoker 1.33 [0.88, 1.99] 0.17 1.43 [0.92, 2.23] 0.11
Ex-smoker 1.79 [1.18, 2.70] 0.006 1.88 [1.20, 2.94] 0.006
Non-smoker Ref. - Ref. -
Unknown 1.60 [0.99, 2.59] 0.05 1.69 [1.01, 2.83] 0.05
HBV status Positive 1.42 [0.96, 2.12] 0.08 1.38 [0.90, 2.12] 0.14
Negative Ref. Ref.
Year of diagnosis /later year 0.93 [0.86, 0.99] 0.04 0.91 [0.84, 0.98] 0.01
CD4 count at diagnosis /50 cells/mm3 higher 0.95 [0.93, 0.98] 0.0001 0.96 [0.94, 0.98] 0.0007
Type of NADC Lung cancer 2.28 [1.75, 2.98] 0.0001 2.43 [1.84, 3.21] 0.0001
Anal cancer 0.58 [0.36, 0.92] 0.02 0.55 [0.33, 0.92] 0.02
Hodgkin’s lymphoma 0.49 [0.32, 0.75] 0.001 0.36 [0.21, 0.60] 0.001
Other Ref. - Ref. -
Lung cancer
HCV status Positive 1.88 [0.97, 3.66] 0.06 2.02 [1.04, 3.95] 0.04
Negative Ref. - Ref. -
Stage of disease Disseminated 5.22 [1.85, 14.76] 0.002 4.84 [1.71, 13.74] 0.003
Localised Ref. - Ref. -
Unknown 5.95 [2.12, 16.74] 0.0007 5.69 [2.02, 16.06] 0.001
Anal cancer
HCV status Positive 4.97 [1.55, 15.89] 0.007 4.16 [1.18, 14.67] 0.03
Negative Ref. - Ref. -
Previous NADC 12.00 [2.98, 48.32] 0.0005 10.17 [1.96, 52.73] 0.006
Stage of disease Disseminated 2.49 [0.73, 8.54] 0.15 2.29 [0.65, 8.10] 0.20
Localised Ref. - Ref. -
Unknown 3.24 [0.94, 11.18] 0.06 2.43 [0.66, 8.95] 0.18
Hodgkin’s lymphoma
HBV status Positive 4.15 [1.16, 14.90] 0.03 3.32 [0.68, 16.21] 0.14
Negative Ref. - Ref. -
CD4 count at diagnosis /50 cells/mm3 higher 0.86 [0.74, 1.01] 0.06 0.80 [0.64, 0.99] 0.04
Haemoglobin at diagnosis /g/L higher 0.72 [0.55, 0.94] 0.02 0.82 [0.59, 1.14] 0.24

Worm et al.

Worm et al. BMC Infectious Diseases 2013 13:471   doi:10.1186/1471-2334-13-471

Open Data