Table 3

Univariate and multivariate Cox models for 7-day mortality with clinical stage as time-dependent covariate
Covariables Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
Age (for each year of increase) 1.02 1.01 – 1.02 <0.001 1.01 1.00 – 101 0.039
Sex
  Female 1 Reference 1 Reference
  Male 1.02 0.81 – 1.27 0.875 0.98 0.76 – 1.27 0.899
Site
  Community 1 Reference 1 Reference
  Hospital 1.29 1.02 – 1.62 0.034 1.33 0.98 – 1.80 0.064
Source of infection
  Urinary 1 Reference 1 Reference
  Respiratory 2.70 1.85 – 3.95 <0.001 1.76 1.12 – 2.77 0.014
  Skin and soft tissues 1.07 0.68 – 1.69 0.776 1.22 0.73 – 2.02 0.441
  Intra-abdominal 2.36 1.52 – 3.65 <0.001 1.50 0.90 – 2.48 0.118
  Other infections 2.34 1.65 – 3.31 <0.001 1.89 1.28 – 2.80 0.001
Comorbidities
  Without comorbidities 1 Reference 1 Reference
  With any comorbidity 1.52 1.17 – 1.98 0.002 0.88 0.65 – 1.20 0.426
SOFA score (0 – 24, for each unit of increase) 1.24 1.21 – 1.27 <0.001 1.09 1.04 – 1.15 0.001
APACHE II score (0 – 67, for each unit of increase) 1.13 1.11 – 1.14 <0.001 1.07 1.04 – 1.10 <0.001
Blood cultures
  Not requested 1 Reference 1 Reference
  Negative 1.07 0.82 – 1.40 0.603 0.91 0.67 – 1.23 0.546
  Gram-positive bacteria 1.37 0.88 – 2.11 0.158 0.83 0.50 – 1.36 0.454
  Gram-negative bacteria 1.04 0.68 – 1.58 0.858 0.59 0.36 – 0.95 0.031
Classification of infection (progression to)
  Infection without sepsis 1 Reference 1 Reference
  Sepsis 2.75 1.47 – 5.15 0.002 1.76 0.93 – 3.33 0.081
  Severe sepsis 4.95 2.71 – 9.06 <0.001 2.13 1.13 – 4.03 0.019
  Septic shock 13.51 7.41 – 24.64 <0.001 3.00 1.50 – 5.98 0.002

León et al.

León et al. BMC Infectious Diseases 2013 13:345   doi:10.1186/1471-2334-13-345

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