Table 2

Univariate and multivariate GEE models for estimating determinants of progression to sepsis, severe sepsis, or septic shock during the first week of hospital stay
Covariables Univariate analysis Multivariate analysis
OR 95% CI P value OR 95% CI P value
Age (for each year of increase) 1.00 (1.00 – 1.01) <0.001 1.00 (1.00 – 1.00) 0.445
Sex
  Female 1 Reference 1 Reference
  Male 1.07 (1.00 – 1.15) 0.037 0.97 (0.92 – 1.02) 0.236
Site
  Community 1 Reference 1 Reference
  Hospital 1.12 (1.04 – 1.20) 0.002 1.03 (0.96 – 1.09) 0.409
Source of infection
  Urinary 1 Reference 1 Reference
  Respiratory 1.53 (1.38 – 1.68) <0.001 1.21 (1.11 – 1.33) <0.001
  Skin and soft tissues 0.81 (0.73 – 0.91) <0.001 0.91 (0.84 – 1.00) 0.041
  Intra-abdominal 1.64 (1.46 – 1.84) <0.001 1.32 (1.20 – 1.46) <0.001
  Other infections 1.33 (1.22 – 1.44) <0.001 1.16 (1.08 – 1.25) <0.001
Comorbidities
  Without comorbidities 1 Reference 1 Reference
  With any comorbidity 1.30 (1.21 – 1.40) <0.001 1.01 (0.95 – 1.07) 0.774
SOFA score (0 – 24, for each unit of increase) 1.21 (1.20 – 1.22) <0.001 1.16 (1.14 – 1.17) <0.001
APACHE II score (0 – 67, for each unit of increase) 1.08 (1.07 – 1.08) <0.001 1.02 (1.02 – 1.03) <0.001
Blood cultures
Not requested 1 Reference 1 Reference
Negative 1.17 (1.09 – 1.27) <0.001 0.96 (0.91 – 1.03) 0.281
  Gram-positive bacteria 1.46 (1.28 – 1.66) <0.001 0.99 (0.88 – 1.11) 0.867
  Gram-negative bacteria 1.58 (1.41 – 1.75) <0.001 1.01 (0.93 – 1.11) 0.748

León et al.

León et al. BMC Infectious Diseases 2013 13:345   doi:10.1186/1471-2334-13-345

Open Data