Table 3

Pre-S region mutations and deletions
Clinical group Genotype Pre-S2 S tart codon Deletions
Region Nucleotides Amino acids Region and functions affected
ID Size Position Size position
SDAC024 CR D ATG Pre-S2 21 35-55a 7 16-22a
SDAC048 CR D ATG Pre-S1 72 2998-3069 24 51-74 S promoter, Transactivator domain
SDAC083 CR D ATG Pre-S2 21 35-55 7 16-22
SDAC097 CR D GTGb Pre-S 2 9 45- 53 3 19-21
SDAC098 CH D ATG Pre-S1 18 3129-3146 6 94-99 Hsc70 binding site, CCAAT binding factor (CBF) binding site, Cytosolic anchorage determinant (CAD)
SDAC112 ASC D ATG Pre-S2 6 49-54 2 20-21
SDAC118 CR D ATG Pre-S2 54 4-57 18 5 to 22 pHSA binding site, Viral secretion
SDAC107 CR D ATA - - - - - -
SDAC090 CR D ATA - - - - - -
SDAC058 CR E ATG Pre-S2 9 58-66c 3 20-22c Transactivator domain
SDAC059 HCC E GTG Pre-S2 12 52-63 4 18-21 Transactivator domain
SDAC088 HCC E ATG Pre-S2 12 52-63 4 18-21 Transactivator domain
SDAC095 HCC E ATG Pre-S2 15 52-66 5 18-22 Transactivator domain
SDAC067 ASC E GTG - - - - - -
SDAC113 ASC A ACA - - - - - -

a nucleotide or amino acid position relative to genotype D (GU456684).

b mutant pre-S2 start codon italicized.

c nucleotide or amino acid position relative to genotype E (AB205191).

Yousif et al.

Yousif et al. BMC Infectious Diseases 2013 13:328   doi:10.1186/1471-2334-13-328

Open Data