MTBs- stimulated IFN-g levels are increased post-therapy in TB patients with deficient more severe TB. Whole blood cells were stimulated with MTBs and IFN-g measured in cell supernatants and compared between patients classified into TB severity classes I, II and III. Responses at 0 and 12 weeks were compared in each group by paired t test analysis. The box and whiskers plots depict cytokine responses in the 10th to 90th percentiles with the horizontal bar indicating the median levels of each group. a, Placebo arm b, Drug intervention arm. ‘*' Denotes p <0.05 between levels at 0 and 12 weeks respectively.
Salahuddin et al. BMC Infectious Diseases 2013 13:22 doi:10.1186/1471-2334-13-22