Table 4

Ligation strength analysis of TgCPB and TgCPL for MHC class II molecules using SYFPEITHI
MHC II Allele1 Start-Stop2 Sequence3 Score4
TgCPB
H2-Ad 55–69 FSAEDVLNAFVSPES 31
H2-Ad 76–90 SIVAEQVVATSGNLT 27
H2-Ad 412–426 KDCEEQAYADNVHPF 27
H2-Ad 117–131 AGELLRLLLADSEDM 26
H2-Ak 43–57 LSEDTSVDPRESFSA 24
H2-Ak 72–86 SLFDSIVAEQVVATS 24
H2-Ak 149–163 IVRDSVLVSEKAFPS 24
H2-Ak 37–51 DDSLFPLSEDTSVDP 22
H2-Ed 313–327 NDRLCIRSQGKRLMP 28
H2-Ed 436–450 AYSLRSRDDVKRDMM 28
H2-Ed 229–243 RFRYLSLKDAKKLMG 26
H2-Ed 309–313 TEAFNDRLCIRSQGK 24
H2-Ek 86–100 SGNLTESAPRDRDSA 24
H2-Ek 313–327 NDRLCIRSQGKRLMP 22
H2-Ek 463–477 EDFLSYKSGVYKHVS 22
H2-Ek 37–51 DDSLFPLSEDTSVDP 20
HLA-DRB1*0101 4–18 RKSFRVLGTPLPFAA 35
HLA-DRB1*0101 13–27 PLPFAALAAILLLGC 34
HLA-DRB1*0101 470–484 SGVYKHVSGLPVGGH 33
HLA-DRB1*0101 71–85 ESLFDSIVAEQVVA T 32
TgCPL
H2-Ad 60–74 RAWIALVAAAVSLLV 31
H2-Ad 68–82 AAVSLLVFASFLIQW 30
H2-Ad 192–206 GVATELLNVLPSELP 30
H2-Ad 58–72 TARAWIALVAAAVSL 27
H2-Ak 18–32 GLENGELHQRRGVRA 22
H2-Ak 146–160 VYIHTHNQQGYSYSL 22
H2-Ak 196–210 ELLNVLPSELPAGVD 22
H2-Ak 256–270 ELMDCSRAEGNQSCS 20
H2-Ed 311–325 VKILGFKDVPRRSEA 30
H2-Ed 44–58 RTYFWKKFLRQRNFT 26
H2-Ed 170–184 RDEFRRKYLGFKKSR 26
H2-Ed 369–383 LVGYGTDKESKKDFW 26
H2-Ek 310–324 VVKILGFKDVPRRSE 24
H2-Ek 77–91 SFLIQWQGEDDRAVF 22
H2-Ek 365–379 HGVLLVGYGTDKESK 22
H2-Ek 6–20 THYVSFLNGEDDGLE 20
HLA-DRB1*0101 59–73 ARAWIALVAAAVSLL 34
HLA-DRB1*0101 60–74 RAWIALVAAAVSLLV 31
HLA-DRB1*0101 195–209 TELLNVLPSELPAGV 31
HLA-DRB1*0101 308–322 EKVVKILGFKDVPRR 30

1 H2-Ad, H2-Ak, H2-Ed and H2-Ek alleles are mouse MHC class II molecules; the HLA-DRB1*0101 allele is a human MHC class II molecule.

2 We chose 15 amino acids for analysis each time.

3 TgCPB or TgCPL sequences.

4 High score = high binding.

Zhao et al.

Zhao et al. BMC Infectious Diseases 2013 13:207   doi:10.1186/1471-2334-13-207

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