Epistatic and co-evolving codons in the structure of Vif protein. 3D structure of a computational model proposed to the Vif protein of HIV-1 (PDB: 1VZF). Epistatic codons are depicted in distinct colors and dashed lines link codon pairs. Co-evolving codons are depicted as magenta sticks in the structure and magenta dashed lines are connecting them. Regions that interact with Apobec3 protein were highlighted in white color in the Vif structure. The BC-Box and the Cullin5-Box were highlighted in yellow color. Panels A, B and C correspond to distinct rotating angles of the structure of Vif.
Bizinoto et al. BMC Infectious Diseases 2013 13:173 doi:10.1186/1471-2334-13-173