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Open Access Highly Accessed Case report

Localized Histoplasma capsulatum osteomyelitis of the fibula in an immunocompetent teenage boy: a case report

Lu Huang, Yongping Wu and Xudong Miao*

Author Affiliations

Department of Orthopedics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou, Zhejiang 310009, P.R. China

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BMC Infectious Diseases 2013, 13:132  doi:10.1186/1471-2334-13-132

Published: 11 March 2013



Infection of local bone with Histoplasma capsulatum is rare and difficult to diagnosis, and occurs particularly in immunocompetent subjects, who are more likely to be affected by a wide range of organisms.

Case presentation

An 11-year-old boy presented with localized histoplasmosis osteomyelitis in the left fibula without any evidence of abnormal immunological function or systemic disease. After surgical clearance of the lesion and homologous cancellous bone, the patient was treated orally with voriconazole for 6 months. The patient completely recovered with full function of his left leg during the 5-year follow-up.


Histoplasmosis osteomyelitis can occasionally occur in immunocompetent individuals and can be complete cured by surgical clearance of the lesion and antibiotic treatment.

Histoplasma capsulatum; Histoplasmosis; Immunocompetence; Osteomyelitis