IFN-γ boxplots of immune reactivity in blood stimulated with antigens/peptides that showed significant differences between groups (group 1, TB + patients, group 2, TB- other pulmonary diseases, group 3, frequent M.tb exposure, yet clinically healthy). Antigens were identified after testing a broad panel of M.tb antigens (see Table 1). Only statistically significant different IFN-γ responses are shown. Strong recognition of Ag85B (Rv1886c), PGL/p-HBAD biosynthesis glycosyltransferase (Rv2958c), PGL/p-HBAD biosynthesis rhamnosyl-transferase (Rv2962c) and PPE55 (Rv3347c). Recombinant proteins Ag85A (Rv3804) and Ag85B (Rv1886c) were differentially recognized among TB + and TB- groups defined by IFN-γ release. The thick lines (inside the boxplots) represent median values.
Alvarez-Corrales et al. BMC Infectious Diseases 2013 13:125 doi:10.1186/1471-2334-13-125