Table 4

Logistic regression analysis of predictors for immunologic failure (Fall of CD4 count to or below baseline or CD4 cell count change < 50 cells/mm3 at one year) among Nigerian adult patients on ART
Characteristics
ALL Immunologic failure Unadjusted p-value Adjusted p-value
(n = 596) (n = 135) OR (95% CI) OR (95% CI)
Gender
Female 377 84 (62%) Ref Ref
Male 219 51 (38%) 1.06 (0.71-1.57) 0.78 1.46 (1.04-2.45) 0.04
Age at HAART Initiation (years)
< 30 178 42 (31%) 1.55 (1.01-2.37) 0.04 1.50 (1.11-2.39) 0.03
>30 357 93 (69%) Ref Ref
Currently married
Yes 336 76 (56%) 0.99 (0.68-1.47) 0.98
No 260 59 (44%) Ref
Residential Distance (in kilometers)
< 50 376 92 (68%) Ref Ref
51 to100 78 19 (14%) 0.99 (0.56-1.75) 0.98 1.19 (0.64-2.33) 0.79
>100 142 24 (18%) 0.63 (0.38-1.03) 0.07 0.68 (0.40-1.21) 0.32
HIV disclosure
Yes 564 129 (22.9%) 0.78 (0.31-1.93) 0.59
No 32 6 (18.8%) Ref
Tuberculosis History
Yes 85 14 (29.6%) 0.64 (0.35-1.17) 0.14 0.66 (0.40-1.36) 0.27
No 511 121 (70.4%) Ref Ref
Baseline anemia (Hemoglobin < 10 g/dl) (n = 546)
Yes 186 40 (20.4%) 1.26 (0.83-1.92) 0.27 1.05 (0.65-1.61) 0.75
No 410 95 (23.7%) Ref Ref
Antiretroviral drug regimen at baseline
ZDV / 3TC / NVP or EFV 242 58 (43%) Ref
D4T / 3TC / NVP or EFV 47 13 (9.6%) 1.21(0.59-2.45) 0.59 1.61 (0.69-3.53) 0.29
TDT / 3TC or FTC / NVP or EFV 307 64 (47.4%) 0.84 (0.56-1.25) 0.38 1.14 (0.77-1.53) 0.83
Drug adherence by pharmacy refill record
>= 95% 549 122 (90.4%) Ref Ref
< 95% 47 13 (9.6%) 1.34 (0.68-2.61) 0.39 1.42 (0.71-2.86) 0.28
Employment status
Employed 496 110 (81.5%) Ref
Unemployed 95 25 (18.5%) 1.25 (0.76-2.07) 0.38
Retired 1 0 (0%) Omitted Omitted
Student 4 0 (0%) Omitted Omitted
Highest educational achievement
No formal education 288 64 (47.4%) Ref
Primary education 134 28 (20.7%) 0.92 (0.56-1.53) 0.76
Secondary education 32 10 (7.4%) 1.59 (0.72-3.53) 0.25
Post-secondary / Tertiary / Advanced education (M.Sc., Ph.D.) 142 33 (24.4%) 1.09 (0.67-1.76) 0.73
Socio-economic class
Class 1 22 4 (3%) Ref
Class 2 91 17 (12.6%) 1.03 (0.31-3.45) 0.96
Class 3 262 68 (50.4%) 1.58 (0.52-4.82) 0.42
Class 4 199 42 (31%) 1.20 (0.39-3.75) 0.75
Class 5 22 4 (3%) 1.00 (0.22-4.63) 1.00
Current smoker
Yes 11 4 (97%) 1.98 (0.57-6.87) 0.28
No 585 131 (3%) Ref
Current drug user
Yes 0 0(0%) Omitted Omitted
No 596 135 (100%) Ref
Current alcohol user
Yes 50 8 (6%) 0.63 (0.29-1.37) 0.24
No 546 127 (94%) Ref
Current herbal drug user
Yes 17 6 (4%) 1.90 (0.69-5.24) 0.21
No 579 129 (96%) Ref

Anude et al.

Anude et al. BMC Infectious Diseases 2013 13:113   doi:10.1186/1471-2334-13-113

Open Data