Table 2

Clinical features of patients with acute bacterial meningitis according to age group*
Group I (non-elderly) Group II (elderly) RR (95% CI) P value
N = 427 N = 208
Interval symptoms-admission (hrs) 24.0 (24.0–37.0) 27.5 (24.0–37.0) ---- 0.3822
Prior antimicrobial therapy (%) 126 (29.5) 77 (37.0) 1.25 (1.00–1.57) 0.0696
Extrameningeal infection(%) 96 (22.5) 79 (37.9) 1.61(1.29–2.00) < 0.0001
Pneumonia (%) 17 (4.0) 20 (9.6) 1.72 (1.25–2.37) 0.0077
ENT infection (%) 56 (8.8) 33 (5.2) 1.16 (0.86–1.56) 0.4149
Urinary tract infection (%) 9 (1.4) 18 (2.8) 2.13 (1.59–2.86) 0.0003
Fever (%) 412 (96.5) 193 (92.8) 0.64 (0.44–0.93) 0.0625
Level of consciousness (%)
Normal (%) 174 (40.7) 49 (23.6) 0.57 (0.43–0.75) < 0.0001
Abnormal (%) 229 (62.6) 142 (68.3) 1.53 (1.20–1.93) 0.0006
Coma (%) 24 (5.6) 17 (8.2) 1.39 (0.95–2.04) 0.1639
Neck stiffness (%) 357 (83.6) 129 (62.0) 0.50 (0.41–0.62) < 0.0001
Meningeal triad present (%) 208 (48.7) 104 (50.0) 1.04 (0.83–1.29) 0.8275
Skin rash (%) 153 (35.8) 19 (9.1) 0.27 (0.17–0.62) < 0.0001
Interval admission-therapy (hrs) 3.0 (1.0–6.0) 4.0 (2.0–12.0) ---- < 0.0001
Focal neurologic signs on admission (%) 63 (14.7) 43 (20.7) 1.30 (1.00–1.69) 0.0777
Seizures on admission (%) 33 (7.7) 13 (6.2) 0.85 (0.53–1.37) 0.6091
Cerebral computed tomography (%) 163 (57.8) 113 (75.8) 1.55 (1.24–1.93) 0.0002

Values expressed as median and interquartile range unless otherwise specified. ENT = ear, nose and throat. *A patient may have more than an extrameningeal focus of infection. Includes: otiitis (73), pneumonia (37), urinary tract infection (27), paranasal sinusitis (23), endocarditis (7), pyelonephritis (4), acute bronchitis (4), tonsillitis (3), parappharyngeal abscess (2), cholecystitis (2), peritonitis (2), ventriculo-peritoneal shunt (2), dental abscess (2), scrotal abscess (1), psoas abscess (1), i.v. catheter (1), pacemaker electrode infection (1).

Domingo et al.

Domingo et al. BMC Infectious Diseases 2013 13:108   doi:10.1186/1471-2334-13-108

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