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This article is part of the supplement: Abstracts from the First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012)

Open Access Poster presentation

Oral lesions among HIV seropositive individuals in an era of generic HAART: markers of HAART efficacy?

Janani Vasudevan1, Vaishnavi Sivasankar1*, Umadevi K Rao1, Nagalingeswaran Kumarasamy2 and Kannan Ranganathan1

Author Affiliations

1 Department of Oral and Maxillofacial Pathology, Ragas Dental College, Chennai, India

2 YRG Centre for AIDS Research and Education, Chennai, India

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BMC Infectious Diseases 2012, 12(Suppl 1):P39  doi:10.1186/1471-2334-12-S1-P39

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2334/12/S1/P39


Published:4 May 2012

© 2012 Vasudevan et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

Oral lesions have been established as a clinical feature of human immunodeficiency virus (HIV) seropositivity. Treatment with Highly Active Antiretroviral Therapy (HAART) has changed the course of infections with HIV. This study correlates the oral lesion prevalence in HAART and non-HAART groups in a cohort of HIV seropositive patients in Southern India.

Methods

The study group consisted of 3485 HIV seropositive patients who reported to the dental clinic of YRG CARE, Chennai, India. Oral lesions were diagnosed clinically based on EC Clearinghouse criteria and the data was analyzed using SPSS software.

Results

In the study population, 92.3% of individuals had acquired the infection through heterosexual contact. The mean age of infected males and females was 35±8 and 30±8 years respectively and the mean CD4 count in males and females was 385.53±226.76 and 284.36±278.28 cells/µL respectively (p<0.05). Patients having CD4 count < 200 (n=908) had more number of oral lesions than patients with CD4 count > 200 (p<0.01). Patients on HAART (n=1042) had a lesser number of lesion than patients not on HAART (p<0.01). Of the lesions, candidiasis was predominantly seen in the non-HAART group (19.7%) as compared to the HAART group (11.7%). Patients who were not on HAART showed a higher prevalence of pseudomembranous candidiasis (12.8% vs.7.9%, p<0.01) and angular cheilitis (6.0% vs.3.7%, p<0.01).

Conclusion

Patients on Highly Active Antiretroviral Therapy (HAART) demonstrate fewer oral lesions, which can serve as markers of treatment efficacy. Long term follow-up studies are necessary to validate these results.