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Open Access Highly Accessed Research article

The distinct category of healthcare associated bloodstream infections

Ryan Lenz1, Jenine R Leal2, Deirdre L Church134, Daniel B Gregson134, Terry Ross4 and Kevin B Laupland135*

Author Affiliations

1 Department of Medicine, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada

2 Infection Prevention & Control - Surveillance, Alberta Health Services, Calgary, Alberta, Canada

3 Department of Pathology and Laboratory Medicine, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada

4 Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada

5 Critical Care Medicine Peter Lougheed Centre, 3500-26th Street NE, Calgary, Alberta T1Y 6J4, Canada

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BMC Infectious Diseases 2012, 12:85  doi:10.1186/1471-2334-12-85

Published: 9 April 2012

Abstract

Background

Bloodstream infections (BSI) have been traditionally classified as either community acquired (CA) or hospital acquired (HA) in origin. However, a third category of healthcare-associated (HCA) community onset disease has been increasingly recognized. The objective of this study was to compare and contrast characteristics of HCA-BSI with CA-BSI and HA-BSI.

Methods

All first episodes of BSI occurring among adults admitted to hospitals in a large health region in Canada during 2000-2007 were identified from regional databases. Cases were classified using a series of validated algorithms into one of HA-BSI, HCA-BSI, or CA-BSI and compared on a number of epidemiologic, microbiologic, and outcome characteristics.

Results

A total of 7,712 patients were included; 2,132 (28%) had HA-BSI, 2,492 (32%) HCA-BSI, and 3,088 (40%) had CA-BSI. Patients with CA-BSI were significantly younger and less likely to have co-morbid medical illnesses than patients with HCA-BSI or HA-BSI (p < 0.001). The proportion of cases in males was higher for HA-BSI (60%; p < 0.001 vs. others) as compared to HCA-BSI or CA-BSI (52% and 54%; p = 0.13). The proportion of cases that had a poly-microbial etiology was significantly lower for CA-BSI (5.5%; p < 0.001) compared to both HA and HCA (8.6 vs. 8.3%). The median length of stay following BSI diagnosis 15 days for HA, 9 days for HCA, and 8 days for CA (p < 0.001). Overall the most common species causing bloodstream infection were Escherichia coli, Staphylococcus aureus, and Streptococcus pneumoniae. The distribution and relative rank of importance of these species varied according to classification of acquisition. Twenty eight day all cause case-fatality rates were 26%, 19%, and 10% for HA-BSI, HCA-BSI, and CA-BSI, respectively (p < 0.001).

Conclusion

Healthcare-associated community onset infections are distinctly different from CA and HA infections based on a number of epidemiologic, microbiologic, and outcome characteristics. This study adds further support for the classification of community onset BSI into separate CA and HCA categories.