Neuronal apoptosis. Caspase-3 immunohistochemistry of 10 μm sections of the middle portion of the hippocampus of the right cerebral hemisphere of mice inoculated with 104 CFU S. pneumoniae at 30 hrs post infection (panel A; 200× magnification). Mice inoculated with S. pneumoniae showed significantly more hippocampal apoptosis at 30 hrs post infection than NaCl infected control mice (panel B, expressed in mean number of Caspase-3 positive cells/section +/- S.E.M.; groups were compared using a Student's t-test; *P < 0.001).
Mook-Kanamori et al. BMC Infectious Diseases 2012 12:71 doi:10.1186/1471-2334-12-71