Table 1

Pregnant women with C. burnetii infection contracted during pregnancy.
Trimester of Exposure Cases [n] Clinical signs of Q fever (n) antibiotic treatment (n) Gestational week at delivery Condition of the infant (n) PCR on placenta positive culture on placenta positive PCR on colostrum/ milk positive PCR on amniotic fluid positive Ph1-IgG > 1:800
1 3* fever (1), none (2) Until delivery: 40 syndactyly2 (1), well3 (1) 0/2 0/1 0/1 0/2 1
 · Clarithromycin (1)
 · Trimethoprim-Sulfamethoxazol (1)
 · (Sulfadiazin + Pyrimethamin for 2 weeks); Trimethoprim-Sulfamethoxazol + Pyrimethamin 1 (1)
2 4 none (4)  · Trimethoprim-Sulfamethoxazol for one week (2) 40 RAD (1), well (3) 0/4 0/3 1/3 0/3 1
 · Clarithromycin after delivery (1)
 · Trimethoprim-Sulfamethoxazol for four weeks (1)
3 4 pneumonia**(1), fever (1), none (2)  · Erythromycin/Clarithromycin for three weeks (1) 35-40 RDS (1), well (3), Oligoamnios (1) 0/2 0/2 0/1 0/14 0
 · without (2)
 · Amoxicillin followed by Imipenem (1)

NOTE. * maternofetal death caused by an underlying disease other than Q fever (n=1), ** confirmed by Xray; 1 additional Toxoplasmose infection in pregnancy; 2toes II-III; 3 no C. burn-specific IgM-antibodies; 4 additional PCR on cord blood negative; RAD, respiratory adaption disorder; RDS, respiratory distress syndrome.

Boden et al.

Boden et al. BMC Infectious Diseases 2012 12:359   doi:10.1186/1471-2334-12-359

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