Table 6

Predictors of adverse outcome, logistic regression analysis
Characteristic Good outcome Adverse outcome Univariate Multivariate, OR, 95% CI, p-value
GOS > 3, alive GOS≤3/death OR, 95% CI
Age, mean (SD) 45 (15.9) 52 (15.6) 1.03, 1.0-1.06 1.02,0.98-1.07, p=0.28
No predisposing factors 48 7 (13%) 3.5, 1.3-9.4 9.3, 1.6-54.7, p=0.014
Comorbidity 31 16 (34%)
GCS at presentation
 12-15 68 11(14%) 1.0 1.0
 8-11 7 3 (30%) 1.7, 0.6-12 3.5, 0.7-17.5, p=0.113
 <8 1 8 (89%) 26.5, 3.6-381 80.6, 2.5-2574, p=0.013
Burr hole aspiration 54 (79%) 14 (21%) 1.0
Craniotomy 17 (81%) 4 (19%) 0.9, 0.3-3.1
Medical 8 (62%) 5 (38%) 2.4, 0.7-8.5
Duration of symptoms before admission, days median (IQR) 4.0 (0–10) 3.0 (0–7) 0.99, 0.97-1.03
Time from admission to surgery, days median (IQR) 5.0 (1–13) 7.0 (1–14) 1.02, 0.97-1.07
Intraventricular rupture of brain abscess 4 (40%) 6 (60%) 6.6 ,1.7-26.2 11.5, 2.5-53.2, p=0.002
Meningitis* 20 (25%) 11 (48%) 2.7, 1.03-7.1 1.5, 0.3-6.3, p=0.597
Streptococcus species 45 (82%) 10 (18%)
Staphylococci 9 (60%) 6 (40%)
Gram-negative species 5 (83%) 1 (17%)
Anaerobic bacteria 7 (87%) 1 (13%)
Other 4 (100%) 0
Negative culture 9 (54%) 5 (36%)
Total n 79 (77%) 23 (23%)

GOS: Glasgow Outcome score, GCS: Glasgow Coma Score, IQR: Inter quartile range. Bacterial species were omitted from logistic regression analysis due to limited number in each group and no significant difference in outcome in univariate analysis. *: Defined as positive spinal fluid culture and/or elevated CSF leukocytes (>15 cells/ μl).

Helweg-Larsen et al.

Helweg-Larsen et al. BMC Infectious Diseases 2012 12:332   doi:10.1186/1471-2334-12-332

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