Table 3

Co-resistance among macrolide-resistant isolates of Streptococcus pneumoniae, 2005-2009
Antibiotic nonsusceptibility erm(B) erm(B)+mef(E) mef(E) mef(A)
(n=75) (n=64) (n=110) (n=14)
CLSI EUCAST CLSI EUCAST CLSI EUCAST CLSI/EUCAST
Penicillin-nonsusceptible
 MIC50/90 (MIC range) 1/2 (0.125-2) 2/4 (0.25-4) 0.25/2 (0.125-4)
  Intermediate 43 (57.3)a,b 58 (77.3)c 21 (32.8) 52 (81.2) 85 (77.3) 105 (95.5) 0
  Resistant 15 (20) 0 43 (67.2) 12 (18.8) 22 (20) 2 (1.8) 0
Clindamycin 75 (100) 75 (100) 64 (100) 64 (100) 0 0 0
Tetracycline 55 (73.3) 55 (73.3) 63 (98.4) 63 (98.4) 40 (36.4) 40 (36.4) 0
Chloramphenicol 41 (54.7) 41 (54.7) 1 (1.6) 1 (1.6) 0 0 0
TMP-SMZ 62 (82.7) 61 (81.3) 64 (100) 64 (100) 48 (43.6) 45 (40.9) 0
MDR 74 (98.7) 73 (97.3) 64 (100) 64 (100) 48 (43.6) 46 (41.8) 0

aNumber in parentheses is percent, unless otherwise indicated.

bOral penicillin V breakpoints.

cBenzylpenicillin breakpoints (infections other than meningitis).

TMP-SMZ: trimethoprim-sulfamethoxazole; MDR: multidrug-resistant.

Grivea et al.

Grivea et al. BMC Infectious Diseases 2012 12:255   doi:10.1186/1471-2334-12-255

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