Table 3

Diagnostic significance of PCT, PCT kinetics, WBC, and CRP for CRBSI during ICU stay
AUC (95% CI) Cut-off Sensitivity (%) Specificity (%) PPV (%) NPV (%) LR(+) LR(−) Accuracy (%)
PCT D0 [ng/ml] 0.990 (0.972 – 1.000) >0.70 92.3 (73.4 – 98.7) 100 (80.0 – 100) 100.0 90.9 n.a. 0.08 95.7
ΔPCTD-1, D0 [ng/ml] 0.982 (0.941 – 1.000) >0.20 100 (84.0 – 100) 95.0 (73.1 – 99.7) 96.3 100.0 20.0 0.0 97.8
ΔPCTD-2, D0 [ng/ml] 0.992 (0.975 – 1.000) >0.20 100 (84.0 – 100) 95.0 (73.1 – 99.7) 96.3 100.0 20.0 0.0 97.8
ΔPCTD-3, D0 [ng/ml] 0.980 (0.939 – 1.000) >0.20 96.2 (78.4 – 99.8) 95.0 (73.1 – 99.8) 96.2 95.0 19.2 0.04 95.6
ΔPCTD-4, D0 [ng/ml] 0.982 (0.946 – 1.000) >0.20 96.2 (78.4 – 99.8) 95.0 (73.1 – 99.8) 96.2 95.0 19.2 0.04 95.6
WBC D0 [10 3/μl] 0.539 (0.369 – 0.709) >15.64 57.7 (37.2 – 76.0) 60.0 (36.4 – 80.0) 65.2 52.2 1.44 0.71 58.7
CRP D0 [mg/dl] 0.603 (0.438 – 0.768) >16.90 50.0 (30.4 – 69.6) 70.0 (45.7 – 87.2) 68.4 51.9 1.67 0.71 58.7

AUC (95% confidence interval, CI), positive (PPV) and negative (NPV) predictive value, LR(+) likelihood ratio positive, and LR(−) likelihood ratio negative.

Theodorou et al.

Theodorou et al. BMC Infectious Diseases 2012 12:247   doi:10.1186/1471-2334-12-247

Open Data