Table 2

Patient’s clinical characteristics on the day of infection (D0), PCT kinetics the previous 4 days until D0 and diagnostic criteria for CRBSI
Not proven CRBSI Proven CRBSI P
n = 20    n = 26
Time elapsed from ICU admission [days; mean (SD)] 10.70 (2.62) 11.77 (3.31) 0.242a
Catheter in place [days; mean (SD)] 8.25 (1.41) 8.73 (2.05) 0.375a
Presence of SIRS [no (%)] 20 (100) 26 (100) 1.0 b
WBC count 10 3/μl; mean (SD)] 14.68 (3.8) 15.37 (6.03) 0.658a
CRP [mg/dl; median (IQR)] 12.75 (7.93-18.33) 15.78 (10.59-21.48) 0.236c
SOFA score [mean (SD)] 5.85 (2.41) 7.19 (2.70) 0.087a
Shock [no (%)] 9 (45.0) 14 (53.8) 0.552b
PCT [ng/ml; median (IQR)]
D-4 (20/26) d 0.15 (0.10-0.20) 0.20 (0.10-0.50) 0.289c
D-3 (20/26) d 0.10 (0.10-0.28) 0.25 (0.10-0.63) 0.017c
D-2 (20/26) d 0.10 (0.10-0.20) 0.50 (0.20-1.40) <0.001c
D-1 (20/26) d 0.10 (0.10-0.30) 0.75 (0.40-2.50) <0.001c
D0 (20/26) d 0.10 (0.10-0.27) 7.70 (2.50-11.43) <0.001c
ΔPCTD-4, D0 0.00 (−0.90-0.40) 7.05 (2.40-10.43) <0.001c
ΔPCTD-3, D0 0.00 (−0.90-0.40) 6.45 (2.40-10.30) <0.001c
ΔPCTD-2, D0 0.00 (−0.60-0.40) 5.55 (2.23-9.93) <0.001c
ΔPCTD-1, D0 0.00 (−0.40-0.10) 4.85 (1.00-9.28) <0.001c
Diagnosis of CRBSI
Criterion 1 [no (%)] _ 6 (23.1)
Criterion 2 [no (%)] _ 10 (38.5)
Both criteria (1 + 2) [no (%)] _ 10 (38.5)

a Student’s t test; b Chi-square test; c Mann–Whitney test; d No of patients available for analysis (Not proven/proven).

Theodorou et al.

Theodorou et al. BMC Infectious Diseases 2012 12:247   doi:10.1186/1471-2334-12-247

Open Data