Table 1

Clinical characteristics of community-acquired and healthcare-associated infections in patients with community-onsetKlebsiella pneumoniaebloodstream infection
CA-KpBSI HCA-KpBSI p
(n = 240) (n = 313)
Age (years) (mean ±SD) 63.0 (±13.6) 60.3 (±12.9) 0.015
Male sex 142 (59.2) 206 (65.8) 0.124
Underlying disease
  Diabetes mellitus 74 (30.8) 71 (22.7) 0.031
  Chronic liver disease 39 (16.3) 84 (26.8) 0.003
  Biliary tract disease 42 (17.5) 43 (13.7) 0.224
  Chronic kidney disease 13 (5.4) 19 (6.1) 0.774
  Respiratory disease 18 (7.5) 21 (6.7) 0.719
  Solid tumor 58 (24.2) 180 (57.5) <0.001
  Hematologic malignancy 4 (1.7) 23 (7.3) 0.002
  Solid organ transplantation 5 (2.1) 9 (2.9) 0.557
Charlson’s WIC (≥3) 47 (19.6) 141 (45.0) <0.001
Primary infection site
  Urinary tract 31 (12.9) 34 (10.9) 0.457
  Peritoneum 11 (4.6) 46 (14.7) <0.001
  Pancreatobiliary tract 82 (34.2) 102 (32.6) 0.696
  Liver 67 (27.9) 41 (13.1) <0.001
  Lung 16 (6.7) 28 (8.9) 0.326
  Skin and soft tissue 4 (1.7) 8 (2.6) 0.477
  Bone 4 (1.7) 2 (0.6) 0.411
  Central nervous system 1 (0.4) 0 (0) 0.434
  Othersa 1 (0.4) 3 (1.0) 0.637
  Unknown 21 (8.8) 52 (16.6) 0.007
Metastatic infection 11 (4.6) 9 (2.9) 0.286
Endophthalmitis 5 (2.1) 3 (1.0) 0.303
Pitt bacteremia score (≥4) 36 (15.0) 56 (17.9) 0.366
Shock at presentation 55 (22.9) 101 (32.3) 0.015
Neutropenia at presentation 3 (1.3) 42 (13.4) <0.001
Polymicrobial infection 34 (14.2) 47 (15.0) 0.780
Initial antimicrobial regimen
  Piperacillin-tazobactam 9 (3.8) 30 (9.6) 0.008
  Quinolone 23 (9.6) 18 (5.8) 0.088
  1st generation cephalosporin 2 (0.8) 0 (0) 0.188
  3rd generation cephalosporin 173 (72.1) 186 (59.4) 0.002
  Carbapenem 30 (12.5) 48 (15.3) 0.342
Inappropriate empirical antimicrobial therapy 14 (5.8) 26 (8.3) 0.266
Inappropriate definitive antimicrobial therapyb 7/223 (3.1) 7/278 (2.5) 0.675
30-day mortality 27 (11.3) 70 (22.4) 0.001

Data indicate no. (%) of patients. WIC, weighted index of co-morbidity; CA-KpBSI, community-acquired Klebsiella pneumoniae bloodstream infection; HCA-KpBSI, healthcare-associated Klebsiella pneumoniae bloodstream infection. a Others were one appendicitis, one pericarditis and two periodontitis. b 52 patients were excluded from the analysis (15 patients were transferred to other hospitals and 37 died before the culture results were available).

Jung et al.

Jung et al. BMC Infectious Diseases 2012 12:239   doi:10.1186/1471-2334-12-239

Open Data